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Post Idea #1: HUON Aquaculture

Related Articles – Summarized

Local Business In The Huon Valley Southern Tasmania

Huon Aquaculture was founded in the picturesque Huon Valley in 1986 by Peter and Frances Bender.

What began as a small family operation has grown to become an employer of over 700 people across Australia and a producer of premium Huon Salmon and Ocean Trout, now a fully owned subsidiary of JBS Foods.

As you travel through the Huon Valley you will get glimpses of Huon’s freshwater hatcheries and see Fortress Pens standing proud on the Huon River and D’Entrecasteaux Channel.

Huon Salmon and Ocean Trout can be purchased from local retailers, online or at Huon’s Farm Gate Shop.

Huon Aquaculture

Today is UN World Wildlife Day, established to recognise and celebrate the world’s animal species.

We’re taking this opportunity to celebrate some of the numerous furry, feathered and quilled creatures we have co-habitating at our sites.

Introducing Edith Echidna who lives at our Springfield hatchery in Tassie’s NE. Huon also has a dedicated Wildlife team who actively work to minimise animal interactions on our marine farms by undertaking safe retrieval and release of wildlife if entry into a pen does occur as well as problem solving causes of pen breaches.

While they largely work to prevent seals from entering pens, they are experts on minimising interactions with sea birds and other marine mammals.

See the comments section below for pics of Percy Platypus who lives with our salmon broodstock at our Lonnavale hatchery in the State’s Huon Valley and Dora Dolphin, just one of many cetaceans our crews see every day across our marine leases in the Huon River, Channel and Storm Bay..

Huon Aquaculture

Huon Aquaculture is a large aquaculture and food processing enterprise located in Tasmania.

Founded in 1986, Huon has grown to become second largest salmon producer in the state, after ASX listed Tassal, it employs 487 Tasmanians and produces 25,000 tonnes of salmon annually.

It became a subsidiary of the Brazilian meat processing company JBS S.A. in November 2021.

Huon operates fish pens in Storm Bay, off Bruny Island, Macquarie Harbour, near Strahan, and Hideaway Bay, near Dover, a fish processing, packing and value-added facility in Parramatta Creek, Tasmania.

In 2020, Huon Aquaculture was convicted of environmental breaches in regard to its operations at Whale Point and fined $40,000.

As of 2021, Huon has additional assets in Western Australia including a processing facility in Perth and a 2,200 hectare lease in the Mid West aquaculture zone.

It was a majority family and employee owned company listed on the ASX, but was acquired by JBS in November 2021.

JBS’ $425 MIllion Acquisition Of Huon Aquaculture – Global Legal Chronicle

MinterEllison have advised JBS S.A. on the acquisition of Huon Aquaculture Group Limited by way of a scheme of arrangement.

Brazilian meat-processing giant JBS S.A has acquired taken the keys to the Tasmanian salmon farming company Huon Aquaculture business after a $425 million takeover.

This followed JBS and Huon’s entry into a binding scheme implementation deed on 6 August 2021.

This was after Huon’s strategic review and subsequent competitive bid process in which JBS was named preferred bidder.

Headquartered in Sao Paulo, JBS S.A. is a leading global food company.

JBS Australia is Australia’s largest meat and food processing company, with a diversified product portfolio including fresh and frozen meats.

Huon was an ASX-listed aquaculture business, with production and processing facilities for Huon salmon and Huon ocean trout.

Suitors Lining Up For Troubled Huon Aquaculture, Including JBS

Tasmania, Australia-based Huon Aquaculture is entertaining offers from a number of suitors interesting in acquiring the struggling salmon-farming firm.

JBS is one of several global food players “Looking to increase their footprint in the aquaculture industry,” Baker said, and acquiring Huon would give Sealord “a potential international look.”

A representative of JBS’ commercial seafood operations confirmed with SeafoodSource the company’s desire to expand operations in the salmon business, but did not comment on its interest in Huon.

The Australian has also reported on JBS’ interest in Huon, and The Mercury reported private equity firm Pacific Equity Partners and West Australian mining magnate Andrew “Twiggy” Forrest are also among the parties interested in Huon.

Tattarang Chief Investment Officer John Hartman said in a statement at the time Huon Aquaculture was “Recognized internationally for producing and showcasing some of Australia’s best aquaculture products with the rest of the world.”

Baker, of Shadforth Financial, said any transaction involving Huon would likely result in the departure of the Benders from leadership posts with the company.

Contacted on 29 July by SeafoodSource, company spokesperson Giles Rafferty declined to comment on whether Huon will be sold.

Huon Aquaculture is hoping JBS’s takeover will mature this financial year.

Huon said it was expecting conditions to improve in 2022.”The outlook for revenue is more positive compared to this time last year,” it told the exchange.

“Retail demand in the domestic market has returned to its long-term average growth rate of 10 per cent and Huon will deliver its first full twelve months of sales under two new three-year contracts with Coles and Woolworths.”

JBS’s takeover bid will play out over the next few months.

A scheme booklet will be sent out to shareholders outlining the details and benefits of the deal in September and then they will vote at a shareholder meeting a month later.

Post Idea #2: Aquaculture of salmonids

Related Articles – Summarized

Aquaculture Of Salmonids

Chile is close to large forage fisheries which supply fish meal for salmon aquaculture.

Modern commercial hatcheries for supplying salmon smolts to aquaculture net pens have been shifting to recirculating aquaculture systemss where the water is recycled within the hatchery.

Farm raised salmonids are also fed the carotenoids astaxanthin and canthaxanthin, so their flesh colour matches wild salmon, which also contain the same carotenoid pigments from their diet in the wild.

The ‘enhanced’ production of salmon juveniles – which for instance lead to a double-digit proportion of the Alaska’s yearly ‘wild’ salmon harvest – is not void of controversy, and the Alaska salmon harvest are highly dependent on the operation of Alaska’s Regional Aquaculture Associations.

“Contaminants are commonly found in the flesh of farmed and wild salmon. Health Canada in 2002 published measurements of PCBs, dioxins and furans and PDBEs in several varieties of fish. The farmed salmonids population had nearly 3 times the level of PCBs, more than 3 times the level of PDBEs, and nearly twice the level of dioxins and furans seen in the wild population. On the other hand,”Update of the monitoring of levels of dioxins and PCBs in food and feed”, a 2012 study from the European Food Safety Authority, stated that farmed salmon and trout contained on average a many times lesser fraction of dioxins and PCBs than wild-caught salmon and trout.

The decrease in survival or abundance often exceeds 50%. However, these studies are all correlation analysis and correlation doesn’t equal causation, especially when similar salmon declines were occurring in Oregon and California, which have no salmon aquaculture or marine net pens.

Recirculating aquaculture systems make it possible to farm salmon entirely on land, which as of 2019 is an ongoing initiative in the industry.

Infogalactic: The Planetary Knowledge Core

The percentage of the Alaska salmon harvest resulting from ocean ranching depends upon the species of salmon and location, however it is all marketed as “Wild Alaska salmon”.

Wild salmon require about 10 kg of forage fish to produce a kg of salmon, as part of the normal trophic level energy transfer.

In 2011, Scotttish salmon farming introduced the use of farmed wrasse for the purpose of cleaning farmed salmon of ectoparasites.

Within the farmed salmon, European salmon had the highest levels, and Chilean salmon the lowest.

These studies are all correlation analysis and correlation doesn’t equal causation, especially when similar salmon declines were occurring in Oregon and California, which have no salmon aquaculture or marine net pens.

Independent of the predictions of the failure of salmon runs in Canada indicated by these studies, the wild salmon run in 2010 was a record harvest.

BC Salmon Facts Salmon farming industry site explaining salmon farming in British Columbia, Canada.

A Global Assessment Of Salmon Aquaculture Impacts On Wild Salmonids

Since the late 1980s, wild salmon catch and abundance have declined dramatically in the North Atlantic and in much of the northeastern Pacific south of Alaska.

In these areas, there has been a concomitant increase in the production of farmed salmon.

Previous studies have shown negative impacts on wild salmonids, but these results have been difficult to translate into predictions of change in wild population survival and abundance.

We compared marine survival of salmonids in areas with salmon farming to adjacent areas without farms in Scotland, Ireland, Atlantic Canada, and Pacific Canada to estimate changes in marine survival concurrent with the growth of salmon aquaculture.

Through a meta-analysis of existing data, we show a reduction in survival or abundance of Atlantic salmon; sea trout; and pink, chum, and coho salmon in association with increased production of farmed salmon.

In many cases, these reductions in survival or abundance are greater than 50%. Meta-analytic estimates of the mean effect are significant and negative, suggesting that salmon farming has reduced survival of wild salmon and trout in many populations and countries.

Trends In Salmonid Recirculating Aquaculture Systems

Existing aquaculture operations are demonstrating that land-based closed-containment technology is adequate for the production of salmon smolts, as well as caviar and many varieties of food fish.

If farms can exclude obligate fish pathogens, the result is consistently healthier fish, reduced mortality and improved performance compared to more open systems.

Land-based salmon growout received positive news in January, as a committee appointed by the Norwegian Ministry of Fisheries concluded that no license fees or quotas should be required for land-based salmon production in Norway.

These new developments are expected to provide a strong market incentive that costs the government nothing, but makes it more attractive to raise salmon in land-based systems.

Although not yet producing salmon in this manner, at least one company plans to produce food-size salmon in land-based systems in Norway.

TCFFI is now working on its fifth and sixth trials evaluating growout of Atlantic salmon to food size of 4 to 6 kg in land based closed-containment systems.

The authors have also learned that careful consideration must be given to minimizing the early maturation of male salmon and depurating the harvested salmon to purge an earthy flavor produced by bacteria in the RAS. At TCFFI, food-size salmon are purged for at least one week during the finishing phase.

Production of salmon forms the fastest growing food producing industry in the world, with annual growth of 7%. Atlantic salmon, Salmo salar, is iconic, high value, widely traded global fish product, and natural stocks are often threatened by overexploitation and habitat degradation.

The main value-added products of salmon include fillets, salmon bread, sushi, and smoked salmon.

1 Incidences of diseasesThe main diseases in farmed salmons include infectious salmon anemia, characterized by pale gills and fish that swim close to the water surface while gulping for air.

Common risk factors that induce outbreaks of furunculosis in salmon farms include: migration of fish, water quality, sharing or transfer of staff among salmon farms and hatcheries, breach of quarantine protocols and poor husbandry and hygienic practices of hatcheries and farms.

These marine fish species are often targeted as sources of fish meal and fish oil for salmon feed production because they provide appropriate nutrients for carnivorous fish species and offer appropriate amounts of polyunsaturated fatty acids, in the fillets of the salmon, which is beneficial for human health.

Notwithstanding the benefits of using fish meal and oils in salmon diet for human health, the practice not only makes salmon diets expensive, but also increases overfishing of target marine fish species, and so runs contrary to sound principles of conservation of aquatic biodiversity.

These research efforts, among a majority of other and ongoing studies, are being incorporated in to breeding schemes by salmon farmers, and demonstrate the importance of salmonids both as high value fish food and sentinel species for human consumption and conservation respectively, and partly explain why farmed salmon production is always on the increase.

We know there are already introduced fish species in the rivers and lakes of the country, and some species may complete life cycles involving marine environments02.

In countries like Chile or Argentina, this is complicated by the fact that salmonids are an exotic species, leading to different impacts to those felt in areas where the species is native.

The presence of new diseases may be due to the pre-existence of the pathogen for the farmed species, the adaptation of a pathogen from one species to another, the introduction of a pathogen by way of ballast water of ships, and the introduction of pathogens through imported eggs42.

Fishing pressure on wild species for fishmeal and oil Salmon farming growth increased the exploitation of wild species for fishmeal and fish oil.

Law 27.231 only refers to an aquaculture that is able to maintain itself, in as much as possible, ecologically sustainable in time, making the aquaculture company accountable, in the case of exotic species, for ensuring the contention of the farmed fish in the exploitation space, forbidding access to waterways that drain in the sea, in the case of marine species in order to avoid, in as much as possible, any genetic contamination of the native fauna.

The ENB assigns one of the priority national objectives to invasive alien species to implement a system coordinated and integrated by national authorities with expertise to warn, early detect, control and/or eliminate invasive or alien species, naturalized or not, that may affect negatively biodiversity.

Target 15.8 aims “by 2020 introduce measures to prevent the introduction and significantly reduce the impact of invasive alien species on land and water ecosystems, and control or eradicate the priority species”.

Post Idea #3: Healthcare Information and Management Systems Society

Related Articles – Summarized

Healthcare Information And Management Systems Society

DIGITAL HEALTH. HIMSS22 Digital will take place March 14-17, 2022, with more than 30 hours of compelling and inspirational content – separate from the in-person stage in Orlando.

Find attendee resources, travel and venue information.

Healthcare Information And Management Systems Society

DIGITAL HEALTH. HIMSS22 Digital will take place March 14-17, 2022, with more than 30 hours of compelling and inspirational content – separate from the in-person stage in Orlando.

Find attendee resources, travel and venue information.

Healthcare Information And Management Systems Society

Morehouse School of Medicine and Healthcare Information and Management Systems Society are collaborating to promote and support the institution’s new Master of Science in Health Informatics program and the Bridge to Health Informatics Pipeline Program.

Opportunity for HIMSS to champion workforce development, diversity, and equity in the healthcare industry.

Morehouse School of Medicine is committed to improving the health and well-being of individuals and communities, increasing the diversity of the health professional and scientific workforce, and addressing primary health care through programs in education, research, and service.

HIMSS Global Health Equity Network is dedicated to improving health care in quality, safety, cost-effectiveness, and access through the best use of information technology and management systems.

MSM and HIMSS recognize the opportunity and growth within telemedicine and health informatics, and the MSHI program aims to prepare and train future healthcare leaders.

Healthcare Information And Management Systems Society

The Healthcare Information and Management Systems Society is an American not-for-profit organization dedicated to improving health care in quality, safety, cost-effectiveness and access through the best use of information technology and management systems.

HIMSS was organized in 1961 as the Hospital Management Systems Society, an independent, unincorporated, nonprofit association of individuals.

In 1963, the second national HIMSS convention was held in Chicago, and the following year the HIMSS national headquarters were moved there.

HIMSS’ Electronic Medical Record Adoption Model is the most widely used assessment of digital excellence in healthcare internationally.

Along with the Radiological Society of North America, HIMSS is a sponsor of the Integrating the Healthcare Enterprise initiative.

With 76 partnering organizations, HIMSS sponsors National Health IT Week, a collaborative forum during which key healthcare constituents – vendors, provider organizations, payors, pharmaceutical/biotech companies, governmental agencies, industry/professional associations, research foundations, and consumer protection groups – work together to elevate national attention to the necessity of greater health IT adoption.

On January 16, 2019, the company announced the sale of its HIMSS Analytics platform to Definitive Healthcare.

Healthcare Information & Management Systems Society

The Healthcare Information & Management Systems Society Global Health Conference & Exhibition is the premier event for more than 40,000 health information and technology professionals, clinicians, executives, and market suppliers from all over the globe.

This event offers exceptional and exclusive education, veteran speakers, and revolutionary products among many.

HIMSS serves business owners, professionals, and decision-makers from the healthcare information and management systems industry.

This event is attended by health professionals with the unwavering passion to advance humanity’s fight against dreaded diseases.

Click this link if you’re interested to become an exhibitor in HIMSS. How to Become a Sponsor in Healthcare Information & Management Systems Society 2021?

Conversations About HIMSS. Here’s why you should join the HIMSS annual meeting.

It’s time to experience the education, innovation, and collaboration of the HIMSS Global Health Conference & Exhibition virtually! t.

Healthcare Information And Management Systems Society :: Pearson VUE

The Candidate Handbook for each HIMSS certification program contains valuable information regarding the certification program’s scope, eligibility requirements, application process, applicable fees, exam content, exam preparatory resources, exam administration logistics, and recertification requirements.

The computer must have a webcam, microphone, speakers, and a stable internet connection, and you must be able to install the Pearson VUE OnVUE app on your computer on the day of your exam appointment.

If you are still unable to pass the 100% system test, or if you will not have the necessary permissions to install the OnVUE app on your exam date, please schedule your exam at a brick-and-mortar Exam Center, instead. After scheduling your exam, please review your appointment confirmation email and ensure that you have the correct exam, date, time, first name and last name matching your government ID, and testing location.

You must contact Pearson VUE or access your online Pearson VUE account to reschedule your exam at least 48 hours prior to your appointment.

You must contact Pearson VUE or access your online Pearson VUE account to cancel your exam at least 48 hours prior to your appointment.

If you have any questions or concerns about the ID you are required to bring with you to the testing center for admittance to your exam, please contact Pearson VUE customer service at home.

By scheduling your exam appointment via OnVUE, you assume the risk of any distractions from or interruptions to your exam administration and waive the liability of Pearson VUE’s, HIMSS’s, and their respective contractors, agents, and representatives for any such negative impacts to your exam experience or results.

HIMSS22 #ReimagineHealthAll of my favorite health tech friends squeezed into one selfie – tell me this isn’t the best selfie you’ve ever seen?!! #hcldr #HITsm #pinksocks #HIMSS22💭 Do you know what makes a great problem-solver? Charles Conn dives into the six mutually reinforcing mindsets research has shown to improve problem-solving in highly uncertain times.

HIMSS22 #HealthcareInnovation #ReimagineHealth”The old teaching ‘they came from an outside hospital or another institution so I don’t have any records’ is becoming less valid of an excuse not to look at patient data because it’s there.” talks about overcoming #interoperability challenges.

HIMSS22 #HealthData”It is exceptionally rare for an entire country to take on measuring their digital maturity. Data & benchmarking presents an unprecedented opportunity to learn where you are today and what tomorrow looks like or could look like.” #HIMSS2022 #digitalhealth.

We ask you to be partners in our efforts to address the inequities that underlie health care.

In the #HIMSS22 maternal health influencers luncheon- in today’s market workers have the power to ask employers for more supportive resources and services provided to new parents returning after parental leave.

Excited to be at 2022! Cris Ross at #HIMSS22 Opening “We are here to redisign, reinvent, reimagine health. It’s overdue!” “So more than a participant in a conference, you are part of a cause!”Reimagine Health #HIMSS22 – Grand Opening with.

Great to be part of a community working for sustainable health all over the world The OCCC is thrilled to welcome back for its Global Health Conference & Exhibition! Thousands of healthcare professionals have traveled to Orlando for #HIMSS22 to learn, connect and find solutions to #ReimagineHealth and wellness for everyone, everywhere.

Post Idea #4: ChannelEngine.com

Related Articles – Summarized

Do More With Online Marketplaces

Full integration means you’ll continue working with your own back end systems.

Our tool ensures product information and stock levels are synchronized and up to date across marketplaces, while orders are pushed back to your own systems.

We’ll fully integrate your store, WMS, ERP or PIM with the most important local and major marketplaces, click & ad channels, and product feeds.

We’re rapidly expanding and including more territories that will help you sell more and grow internationally.

Careers At ChannelEngine

ChannelEngine offers leading brands, distributors, and retailers a solution to sell their products through international marketplaces.

We started ChannelEngine in 2013 when we noticed the world of e-commerce was changing, and marketplaces were becoming more and more critical.

We saw an opportunity to make these powerful platforms available to every business and created ChannelEngine to offer a complete, user-friendly, marketplace management suite.

Nine years later, we facilitate the sale of over 6 million products from 2000 brands to over 200 marketplaces.

Our platform is used by a wealth of robust and well-known companies including the likes of Bugaboo, Hunkemöller, Brabantia, Bosch, JDE, and Reckitt, to name just a few.

Bol.Com: Marketplace Guide

This is a ChannelEngine guide on the Utrecht-based marketplace Bol.com.

Other costs none Payment 21-28 days Product categories almost anything Input language Dutch Input currency EUR Content creation yes Is the marketplace commission available via the API? yes Profile on ChannelEngine Bol.com How to request an account.

If you are a direct Bol.com supplier, please contact your Customer Success Manager and they will add our Bol.com supplier integration plugin.

While Bol.com is mainly an open marketplace, there are requirements that should be met before creating a business account and selling products via Bol.com.

Further details on the requirements set by Bol.com ca be found on Starten met verkopen bij bol.com.

On Bol.com If you wish to verify that ChannelEngine has OAuth access to your Bol.com account, log into your Bol.com account.

Bol.com does not offer a completely automated option for this you can create product families in a few easy steps in the Bol.com back-end.

ChannelEngine Gets $49.8M In Series B Round

ChannelEngine, the online marketplace integration platform, has closed a Series B funding round for 45.5 million euros, according to a press release.

The company wants to “Become the world’s largest ecommerce network and operating platform” using its management suite, which connects brands, wholesalers and retailers with its global eCommerce market.

The release said ChannelEngine is aiming to “Boost international sales” through tools like automated repricing, content, stock and order management.

The release noted that the eCommerce market has been doing well for now and could be worth $5.9 trillion in 2023 as more global marketplaces take form.

The release added that established players like Amazon and eBay are now being joined by more brick and mortar stores moving their markets online.

“We’re in the midst of a profound shift in eCommerce as brands are increasingly selling directly to consumers via open online marketplaces such as Amazon, Walmart and Zalando,” said ChannelEngine CEO and founder Jorrit Steinz.

The two-year tally is reportedly almost $610 billion more than the eCommerce spending total from March 2018 through February 2020, according to the report.

Post Idea #5: Online marketplace

Related Articles – Summarized

The World’S Top Online Marketplaces 2021

We include a detailed breakdown of the top four product categories – fashion, books, homewares and electronics – and finally take a look at the top marketplaces by country and region.

You can find the biggest sellers on these marketplaces in our articles on the world’s top Amazon sellers and the world’s top eBay sellers.

In the top 20 there is a 40/60 split between marketplaces that are retailers themselves, and those that are only marketplaces.

Retailers who have added an online marketplace to their website, such as Zalando and ASOS, make up 15 of the 31 fashion marketplaces.

North American consumers generate the most traffic to online marketplaces, with 4.4 billion visits per month, and 55 different marketplaces having one million or more visits each.

Africa has only 52 million visits to online marketplaces per month, and just six marketplaces breaking the one million visits mark.

The majority of these online marketplaces are Indian companies, and all but Pepperfry are pure-play online marketplaces without retail operations of their own in India.

The 15 Best Online Marketplaces For Ecommerce Retailers

An online marketplace is an ecommerce site where multiple third-party sellers list their products.

Different marketplaces have different fulfillment policies, but this is the basic structure of how online marketplaces work with third-party sellers.

Selling on an online marketplace can also be easier and faster than building your own ecommerce website because the interface is built for you – which often makes it a better experience for shoppers who are already familiar with the site.

Once you’re approved as a third-party seller on an online marketplace, you can simply create your product listings, then you’re ready to sell!

Many online marketplaces also offer third-party sellers opportunities to promote their products to shoppers, such as Amazon Advertising, and options to outsource order fulfillment, such as FBA. 15 top online marketplaces.

We do know that Target prefers to sell products with a proven track record, making Target a better choice for established ecommerce brands than for new online sellers.

The Rakuten marketplace is often called “The Amazon of Japan.” The largest B2B2C ecommerce site in Japan, the Rakuten marketplace has now expanded globally, including a program for US ecommerce sellers.

8 Of The Best Ecommerce Marketplaces For Online Sellers

Just like the department stores of yesteryear and the convenience they offered, shoppers love online marketplaces – so much so, they spent $1.86 trillion globally in 2018!

To help you in your search, here are eight of the best ecommerce marketplaces available.

With 5 million marketplace sellers and 197 million U.S. shoppers browsing the site every month in 2017, Amazon is one of the most popular online marketplaces available.

Etsy caters to shoppers looking for unique products, which makes this online marketplace ideal for small to medium sellers specializing in handmade or vintage products.

Compared to many of the online marketplaces on this list, Jet is the new kid on the block.

Jet is the ideal online marketplace for sellers that cater to a specific customer segment – price-sensitive, millennial city dwellers.

There are lots of online marketplaces to choose from, so to find a match, you have to be clear on your goals and needs.

The Best Online Marketplaces For Selling Your Products

There are also niche online marketplaces like Bonanza and Fruugo and Hollar, fashion-focused marketplaces such as Zalando and Fullbeauty, bargain-focused marketplaces such as Tophatter and Tanga and the list goes on.

There are now over 100 online marketplaces you could potentially leverage to reach customers doing their online shopping – both within the United States and overseas in areas like Japan and Europe, with trillions of dollars in revenue potential just waiting to be tapped.

All of the biggest and most established online marketplaces have programs in place to help you easily navigate the waters of marketing, selling and fulfilling.

If your small business is looking for a fast, easy way to get products in front of shoppers, selling on ecommerce marketplaces is an excellent place to start.

Even if you already have a thriving online store, uploading your products to select ecommerce marketplaces is an excellent way to expand your reach.

Once you get comfortable selling domestically on online marketplaces, the next step is to expand your online business to international audiences.

Whether you’re getting ready to launch a new ecommerce business or have been selling online for years, online marketplaces should be a central part of your strategy.

What Is An Online Marketplace? Definition, Examples, And Benefits

The concept of a marketplace dates back to 3,000 BC, when a marketplace was simply a physical place where vendors could barter and sell goods.

An online marketplace is a website or mobile application that connects buyers and sellers.

In this piece, we’ll dive into the various types of marketplaces, the benefits marketplaces have, and examples of the best online marketplaces gaining traction today.

Tip: Check out this piece on 5 things marketplace sellers need to know about sales tax Online marketplace business models types.

Before Ebay was the giant, auction-based marketplace it is today, it was a niche online auction site for buying and selling rare beanie babies.

A marketplace must also offer a strong value proposition to sellers – and, typically, that value proposition is economic in nature.

No piece on marketplaces would be complete without examples, but rather than rehash the examples that have had more than their fair share of attention, we’ll dive into a few up-and-coming marketplaces that are disrupting their industries.

Online Marketplaces: The World’S Top ECommerce Sites To Sell Your Products On In 2022

One of the greatest reasons you should sell on online marketplaces is the established audiences they have.

The best strategy is to establish your online presence through selling on your own e-Commerce site and expanding to as many online marketplaces as feasible.

If you only sell in the US then look for marketplaces that are popular in the US. If you want to go global then look for global online marketplaces that operate in the specific regions you’re interested in.

There are probably close to 150-200 large online marketplaces around the world.

If are a B2B business and sell services or products to other companies then you have a different set of marketplaces to sell on.

Online marketplaces are a great way to grow any eCommerce business, you just have to find the right ones.

Be sure to check out our other helpful articles on our eCommerce blog like our eCommerce marketing resource guides for more examples of online marketplaces, marketing tips, and ways you could grow your business online.

3 Online Marketplaces Better Than Craigslist

If you’re a seller, here are Craigslist power tips to sell anything quickly.

Once the item is purchased, Poshmark provides a prepaid, preaddressed label to place on the box you mail the item in, and all you have to do is get the item to the post office or have USPS pick up the package.

Poshmark puts “Posh Protect” on all items, guaranteeing refunds to buyers if an item has undisclosed damage, doesn’t match the description, isn’t authentic, or when the item delivered is incorrect or missing from the package.

If you’re selling a laptop, the app will identify the item and quickly categorize it, maximizing exposure to potential buyers.

In the end, buyers and sellers meet in person and verify the quality of the items.

Several fail-safes are unknown to Craigslist: Letgo sellers can be rated and reviewed, giving buyers the chance to warn each other about misleading buyers or lousy products.

The Marketplace is geared toward buying and selling in a local area, and the page automatically lists items from your geographic location to up to 100 miles away.

Post Idea #6: General Catalyst

Related Articles – Summarized

General Catalyst

General Catalyst, formerly General Catalyst Partners, is an American venture capital firm focused on early stage and growth investments.

The firm was founded in 2000 in Cambridge, Massachusetts, and also has offices in San Francisco, Palo Alto, London and New York City.

In 2011, the firm opened an office in Palo Alto and shortly after raised a $500 million fund.

In 2013, it announced a $675 million fund followed by a $845 million fund in 2016.

In 2018, the company raised $1.4 billion for its ninth fund.

In August 2021, General Catalyst announced a deal with for-profit healthcare provider HCA Healthcare to develop digital solutions to streamline workflows and improve patient care; as part of the deal, General Catalyst’s portfolio company Commure bought HCA’s healthcare app development firm PatientKeeper.

U.S. venture firms are flying staff out to Europe and hiring people already on the ground in the region as they look to find the next Spotify or the next ASML, a Dutch semiconductor firm whose market value has grown to $331 billion amid the global chip crunch.

Silicon Valley venture firm Lightspeed Venture Partners, which has invested in Snap and Epic Games, hired Paul Murphy and Ross Mason to lead the company’s push into Europe.

While Europe still lacks a tech behemoth like Apple or Amazon, it is home to an increasing number of tech companies worth tens and even hundreds of billions of dollars and some believe it’s only a matter of time before Europe creates a tech firm on the same scale as the behemoths in the U.S. and Asia.

“The consensus has morphed from believing Europe is a doomed tech backwater, to Europe has emerged as a real global player with multiple category owning companies,” London-based investor Hussein Kanji told CNBC, pointing to Spotify, Klarna, Revolut and Darktrace.

Sequoia has backed more than 10 companies in Europe since opening the London office.

A spokesperson for the firm wasn’t immediately available for comment when contacted by CNBC. Google Ventures launched a dedicated Europe operation in 2015 with five partners based out of London.

GV still invests in Europe but it now uses a global fund instead of a dedicated European one, and the company has gone from having five partners in London to just two.

General Catalyst Doubles Down On Healthcare With $600 Million New Fund

With the pandemic thrusting healthcare technology companies into the forefront over the past year, one of venture capital’s largest firms is launching a large fund to invest even more in innovation in the red-hot sector.

General Catalyst has raised $600 million for a new Health Assurance Fund, the firm says, its first vertical-focused vehicle and one that looks to build on recent success like Livongo, the diabetes monitoring company that was acquired by Teladoc in a $18.5 billion deal that closed last October.

Led by Hemant Taneja, now the firm’s sole managing partner, the new health-focused fund will invest in early-stage and growth-stage healthcare businesses while providing upside to hospital systems and healthcare providers who have joined as limited partners in the fund.

The new fund comes as part of a busy few months of expansion for General Catalyst, the firm founded in 2000 that has more than $8 billion in assets and raised $2.3 billion in funds as recently as last year.

General Catalyst has also worked on three special purpose acquisition companies, or SPACs, recently, including a $500 million healthcare SPAC and a $500 million one focused on the intersection of pharmaceuticals and digital health.

Joining Taneja in the healthcare fund is Chris Bischoff, a healthcare investor based in London who joined General Catalyst from Kinnevik AB in February.

The new healthcare fund will co-invest with General Catalyst’s flagship funds in appropriate opportunities, the firm says, meaning limited partners in those funds won’t necessarily be shut out of deals in the sector, which made up 20% of commitments from its last fund.

Post Idea #7: Microwave oven

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Microwave Ovens

Whether you’re trying a new recipe, reheating your meal for dinner or making popcorn for movie night, a microwave makes your life a whole lot simpler.

At Target, find microwave ovens based on the size of your counter, the wattage you need and the brand you love.

Countertop Microwaves are easy to use and one of the most essential kitchen appliances.

If you’re split between an oven and a microwave, pick the microwave with a built-in convection function.

These microwaves can be used for power grilling, baking and other functions just like an oven.

To avoid the hassle of messy cleanups pick stainless steel microwave ovens that are super easy to clean and maintain.

Whether you choose an over-the-range microwave or a regular one, a microwave oven gives you fast, even, thorough and quick-cooking options.

Microwave Oven

A microwave oven is an electric oven that heats and cooks food by exposing it to electromagnetic radiation in the microwave frequency range.

Microwave oven ownership in Vietnam was at 16% of households in 2008-versus 30% ownership of refrigerators; this rate was up significantly from 6.7% microwave oven ownership in 2002, with 14% ownership for refrigerators that year.

A variant of the conventional microwave oven is the convection microwave oven.

A convection microwave oven is a combination of a standard microwave oven and a convection oven.

Food and cookware taken out of a microwave oven are rarely much hotter than 100 °C. Cookware used in a microwave oven is often much cooler than the food because the cookware is transparent to microwaves; the microwaves heat the food directly and the cookware is indirectly heated by the food.

Direct microwave exposure is not generally possible, as microwaves emitted by the source in a microwave oven are confined in the oven by the material out of which the oven is constructed.

“The Microwave Oven”: Short explanation of microwave oven in terms of microwave cavities and waveguides, intended for use in a class in electrical engineering.

Post Idea #8: Southwest Airlines

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Southwest Airlines On The App Store

Book a flight in just a few easy steps Check in, change or cancel your flights.

You can now use Travel Funds, Southwest LUV Vouchers, and Gift Cards when changing your flight in the app.

Use the app to take you to our Inflight Entertainment Portal1 where you can watch free live TV2, listen to free music from iHeartRadio2, access free on-demand TV episodes, and view free movies.

Thanks to our partnership with Lyft®, you can now use the app to help you request a Lyft®! You’ll know key information like estimated time of arrival and estimated price before booking.

Use our app to quickly book all of your travel needs.

The developer, Southwest Airlines Co., indicated that the app’s privacy practices may include handling of data as described below.

Family Sharing Up to six family members can use this app with Family Sharing enabled.

Airlines, Including American And Southwest Are Cutting Flights This Spring And Summer

According to Henry Harteveldt, a travel industry analyst with Atmosphere Research Group, airlines are making up for past years losses, as well as current inflation.

A Southwest Airlines spokesperson told WFAA that the company cut around 325 flights per day from April 3 to June 4.

American Airlines doesn’t hedge fuel, like Southwest.

Each airline may cite a different reason for cutting flights, but higher costs, competitive staffing and the pandemic have been nonstop factors impacting the industry as a whole.

“All airlines are being affected by a common set of challenges,” said Harteveldt.

Each obstacle is preparing airlines for the next, and Harteveldt believes with every crisis, the industry becomes more resilient.

Most airlines will allow a refund or travel credit if the prices go down, which will protect the customer.

Brokerages Anticipate Southwest Airlines Co. Will Post Quarterly Sales Of $4.52 Billion

Wall Street analysts expect Southwest Airlines Co. to announce $4.52 billion in sales for the current quarter, Zacks reports.

Southwest Airlines reported sales of $2.05 billion in the same quarter last year, which indicates a positive year-over-year growth rate of 120.5%. The business is expected to announce its next earnings report before the market opens on Thursday, April 28th. On average, analysts expect that Southwest Airlines will report full year sales of $21.47 billion for the current financial year, with estimates ranging from $20.63 billion to $22.24 billion.

Zacks’ sales averages are an average based on a survey of sell-side analysts that that provide coverage for Southwest Airlines.

Southwest Airlines had a negative return on equity of 12.89% and a net margin of 6.19%. The firm’s revenue was up 150.9% compared to the same quarter last year.

FNY Investment Advisers LLC acquired a new stake in shares of Southwest Airlines during the 3rd quarter valued at approximately $25,000.

Cornerstone Advisory LLC acquired a new stake in Southwest Airlines in the fourth quarter worth $27,000.

Southwest Airlines Co engages in the operation and management of a passenger airline.

Southwest, United Cut Thousands Of Flights Over Gas Prices, Staff

Southwest Airlines and United Airlines have reported a new slate of reductions to spring flight schedules, citing issues ranging from staffing shortages to high gas prices.

As first reported by The Dallas Morning News’ Kyle Arnold, Dallas-based Southwest Airlines posted a regulatory filing Tuesday showing the company is dropping 65,000 flights from its spring schedule in response to ongoing staffing issues.

” flight schedule is currently published through September 5, 2022, and as previously disclosed, the Company recently reduced its published flight schedules for March through May 2022 due to continuing challenges with available staffing,” the company noted in Tuesday’s filing.

United likewise on Tuesday filed a report noting it will reduce flight capacities, citing “Macroeconomic” factors including fuel prices, supply chain issues and global instability.

“In response to several macroeconomic factors including rising fuel prices as well as expected aircraft delivery delays, has reduced its total capacity plan for the full year 2022 to be down in the high single digits versus full year 2019.”.

United disclosed that the reduction in flights would lead to an increase in the Cost Per Available Seat Mile of several percentage points above previously expected benchmarks.

Travelers are advised to arrive four hours early for international flights and three hours for domestic departures.

Flight Prices Increase: Airlines Say Travel Demand And Fuel Costs Up

In presentations at an investor conference, airline officials said they expect to offset their higher fuel bills with higher ticket prices thanks to surging demand.

That’s bad news for travelers who haven’t bought tickets for spring break or summer vacation yet, as strong bookings enable airlines to raise ticket prices.

Delta Air Lines President Glen Hauenstein said the airline needs to collect an extra $30 or $40 per the average $400 round trip ticket to cover its rising fuel costs and so far is having no trouble doing so given a surge in bookings.

American Airlines CEO Doug Parker said “Demand is higher than it’s ever been” for domestic travel and that overall bookings are “Incredibly strong.” Last week, the airline had three record ticket sales days, he said.

Another COVID-19 wave and other factors could hurt bookings again and reduce airlines’ ability to raise fares, but for now the trend in ticket prices is up.

‘How much can the consumer bear?’The big question for airlines and travelers is how high ticket prices can go before travelers resist.

Do include online travel agencies like Expedia and search engines like Google Flights and Kayak in your research as they combine flights from different airlines for the itinerary, which can save money over flying one airline for the trip.

Southwest Airlines

The airline was established on March 15, 1967, by Herb Kelleher and Rollin King as Air Southwest Co. and adopted its current name, Southwest Airlines Co., in 1971, when it began operating as an intrastate airline wholly within the state of Texas, first flying between Dallas, Houston, and San Antonio.

Southwest Airlines was founded in 1966 by Herbert Kelleher and Rollin King, and in 1967 it was incorporated as Air Southwest Co. Three other airlines took legal action to try to prevent the company from its planned strategy of undercutting their prices by flying only within Texas and thus being exempt from various regulations.

The lawsuits were resolved in 1970, and in 1971 the airline began operating regularly scheduled flights between Dallas Love Field and Houston and between Love Field and San Antonio, and adopted the name Southwest Airlines Co. In 1975, Southwest began operating flights to various additional cities within Texas, and in 1979 it began flying to adjacent states.

In its history, Southwest Airlines has operated only Boeing 737 jetliners, except from 1979 to 1980 and 1983 to 1985 when it leased and operated a few Boeing 727-200s. Southwest is the largest operator of the Boeing 737 worldwide.

In the event of a cancellation, passengers are refunded a travel credit in the amount spent on their ticket, and the credit may be used toward other Southwest Airlines or Southwest Vacations purchase within a year of the original ticket purchase.

The original Rapid Rewards program offered one credit per one-way flight from an origin to a destination including any stops or connections on Southwest Airlines.

In March 1992, shortly after Southwest started using the “Just Plane Smart” motto, Stevens Aviation, which had been using “Plane Smart” for its motto, advised Southwest that it was infringing on its trademark.

Southwest Airlines is bringing back alcoholic beverages on flights this month after suspending their sale in March 2020.

The beverage service is available on flights of 176 miles or more.

“Customers have expressed a desire for more beverage options, so we’re delighted to restore additional on-board offerings as a part of the Southwest hospitality that our customers know and love,” said Tony Roach, vice president of Southwest customer experience and customer relations, in the news release.

The union representing Southwest Airlines flight attendants says resuming alcohol service is “Unsafe and irresponsible.”

Lyn Montgomery of TWU Local 556 says that the union fought Southwest on the move, saying that it makes it hard to enforce the federal mask mandate on board flights as puts flight attendants risk.

American Airlines, the last big holdout on alcohol service, told CNN Friday that it hasn’t set a date for the return of alcohol in its main cabins.

“We will continue to evaluate the situation and work closely with the union that represents our flight attendants, the Association of Professional Flight Attendants, and medical experts on this process to determine when we will return to full service in the main cabin,” the airline said in a statement.

Post Idea #9: Mitsubishi Tanabe Pharma

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Mitsubishi Tanabe Pharma

Mitsubishi Tanabe Pharma Corporation is a Japanese pharmaceuticals company, a subsidiary of Mitsubishi Chemical Holdings Corporation.

Mitsubishi Pharma Corporation was formed in 2001 from the merger of Mitsubishi-Tokyo Pharmaceuticals and Welfide Corporation.

Mitsubishi Tanabe Pharma is a member of the Mitsubishi UFJ Financial Group keiretsu.

Mitsubishi-Tanabe Pharmaceuticals developed the first BET inhibitor molecules.

In 1901, Motosaburo Tanabe, the Twelfth established a pharmacy in Tokyo, which incorporated in 1921 as Motosaburo Tanabe Shoten.

In 1981, Mitsubishi Chemical Industries, Ltd. established a business alliance with Tokyo Tanabe Pharmaceuticals Co. In 1984, Mitsubishi Chemical Industries, Ltd. changed its name to Mitsubishi Chemical Corporation following the merger with Mitsubishi Petrochemical Co., Ltd. In 1999, Mitsubishi Chemical Corporation and Tokyo Tanabe Pharmaceuticals Co. merged formally and formed Mitsubishi-Tokyo Pharmaceuticals, Inc., to take over the combined pharmaceutical operations of the two companies.

On 27 February 2020, Mitsubishi Tanabe Pharma was delisted from the Tokyo Stock Exchange, and is now described as a member of the Mitsubishi Chemical Holdings Group.

Mitsubishi Tanabe Pharma America Presents REFINE-ALS Biomarker Study Details At Virtual 32nd International Symposium On ALS/MND

PRNewswire/ – Mitsubishi Tanabe Pharma America, Inc. today announced virtual poster presentations reviewing the Phase 4 REFINE-ALS biomarker study in people with amyotrophic lateral sclerosis, including an overview of biomarker assays utilized in the study as well as COVID-19 mitigation strategies deployed through protocol amendments.

“ALS patient needs remain MTPA’s primary focus, so it was a priority to address the evolving concerns of the ALS community during the pandemic and offer appropriate alternatives for patients to participate in the REFINE-ALS study through a virtual setting,” said Atsushi Fujimoto.

The REFINE-ALS study, conducted in collaboration with the Massachusetts General Hospital Neurological Clinical Research Institute, is designed to identify and measure specific biomarkers and clinical assessments in up to 300 people with ALS in the U.S. who have begun treatment on RADICAVA®.

“Our ongoing, adaptable collaboration with MTPA has allowed the REFINE-ALS study to continue enrollment and analyses of these complex biomarkers as a way to enhance understanding of ALS treatment.”

1 Edaravone was discovered and developed for ALS by Mitsubishi Tanabe Pharma Corporation and Mitsubishi Tanabe Pharma Development America, Inc., commercialized in the U.S. by Mitsubishi Tanabe Pharma America, Inc. The MTPC group companies began researching ALS in 2001 through an iterative clinical platform over a 13-year period.

You may report side effects to Mitsubishi Tanabe Pharma America, Inc. at 1-888-292-0058 or FDA at 1-800-FDA-1088 or www.

About Mitsubishi Tanabe Pharma Corporation Mitsubishi Tanabe Pharma Corporation, founded in 1678, is one of the oldest pharmaceutical companies in the world.

Post Idea #10: Amyotrophic lateral sclerosis

Related Articles – Summarized

Genetic And Rare Diseases Information Center

Takei K, Tsuda K, Takahashi F, Hirai M, Palumbo J. An assessment of treatment guidelines, clinical practices, demographics, and progression of disease among patients with amyotrophic lateral sclerosis in Japan, the United States, and Europe.

Schultz J. Disease-modifying treatment of amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis, or ALS, is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control.

ALS often begins with muscle twitching and weakness in a limb, or slurred speech.

Eventually, ALS affects control of the muscles needed to move, speak, eat and breathe.

ALS affects the nerve cells that control voluntary muscle movements such as walking and talking.

Some studies examining the entire human genome found many similarities in the genetic variations of people with familial ALS and some people with noninherited ALS. These genetic variations might make people more susceptible to ALS. Environmental factors, such as the following, might trigger ALS. Smoking.

Some evidence suggests that exposure to lead or other substances in the workplace or at home might be linked to ALS. Much study has been done, but no single agent or chemical has been consistently associated with ALS. Military service.

People with ALS can develop malnutrition and dehydration from damage to the muscles that control swallowing.

Amyotrophic Lateral Sclerosis

Some experts believe progressive muscular atrophy represents a form of ALS. The disease is progressive, initially exclusively involving the LMN. Many patients go on to develop clinical signs and symptoms of UMN disease, at which point it is called lower motor neuron-onset ALS. Interestingly, even in those patients who never show clinical evidence of UMN involvement, corticospinal tract involvement is detected at autopsy in up to 50% to 66% of patients with an antemortem diagnosis of PMA.Primary lateral sclerosis is a disorder of initially exclusive UMN disease.

Symptomatic management is the main treatment in patients with amyotrophic lateral sclerosis, and it is recommended that their care team be interprofessional, with caregivers from neurology, physical therapy, occupational therapy, respiratory therapy, dietary, social work and nursing.

Level 2].Review QuestionsFigureMRI GRE sequence demonstrating iron deposition in the precentral gyrus in a patient with amyotrophic lateral sclerosis.

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment: report of the Quality Standards Subcommittee of the American Academy of Neurology.

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies: report of the Quality Standards Subcommittee of the American Academy of Neurology.

37.Körner S, Sieniawski M, Siniawski M, Kollewe K, Rath KJ, Krampfl K, Zapf A, Dengler R, Petri S. Speech therapy and communication device: impact on quality of life and mood in patients with amyotrophic lateral sclerosis.

41.Stone CA, O’Leary N. Systematic review of the effectiveness of botulinum toxin or radiotherapy for sialorrhea in patients with amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis

The progressive degeneration of the motor neurons in ALS eventually leads to their demise.

The motor nerves affected when you have ALS are the motor neurons that provide voluntary movements and muscle control.

For about 90% of all cases, there’s no known family history of the disease or presence of a genetic mutation linked to ALS. For 5-10% of all cases, there’s a known family history of the disease.

Studies to develop more treatments and a cure for ALS, many funded by The ALS Association, are ongoing around the world.

Scientists have made significant progress in understanding how the disease works, identifying biological indicators that can help diagnose and treat the disease, and learning ways to prevent cases of ALS. learning more about the disease.

People living with ALS may experience a better quality of life by participating in support groups and attending one of The ALS Association’s Certified Treatment Centers of Excellence or a Recognized Treatment Center.

Such Centers provide a national standard of best-practice multidisciplinary care to help manage the symptoms of the disease and help people living with ALS live on their own terms for as long as possible.

Amyotrophic Lateral Sclerosis: A Clinical Review

Amyotrophic lateral sclerosis is a neurodegenerative disorder affecting primarily the motor system, but in which extra-motor manifestations are increasingly recognized.

ALS often has a focal onset but subsequently spreads to different body regions, where failure of respiratory muscles typically limits survival to 2-5 years after disease onset.

In 10% of ALS patients, the family history suggests an autosomal dominant inheritance pattern.

The remaining 90% have no affected family members and are classified as sporadic ALS. The causes of ALS appear to be heterogeneous and are only partially understood.

To date, more than 20 genes have been associated with ALS. The most common genetic cause is a hexanucleotide repeat expansion in the C9orf72 gene, responsible for 30%-50% of familial ALS and 7% of sporadic ALS. These expansions are also a frequent cause of frontotemporal dementia, emphasizing the molecular overlap between ALS and FTD. To this day there is no cure or effective treatment for ALS and the cornerstone of treatment remains multidisciplinary care, including nutritional and respiratory support and symptom management.

In this review, different aspects of ALS are discussed, including epidemiology, aetiology, pathogenesis, clinical features, differential diagnosis, investigations, treatment and future prospects.

Keywords: TDP-43 pathology; amyotrophic lateral sclerosis; sporadic and familial ALS..

Amyotrophic Lateral Sclerosis

There is debate over whether PLS and PMA are separate diseases or simply variants of ALS. Classic ALS accounts for about 70% of all cases of ALS and can be subdivided into limb-onset ALS and bulbar-onset ALS. Limb-onset ALS begins with weakness in the arms and legs and accounts for about two-thirds of all classic ALS cases.

Bulbar onset is associated with a worse prognosis than limb-onset ALS; a population-based study found that bulbar-onset ALS has a median survival of 2.0 years and a 10-year survival rate of 3%, while limb-onset ALS has a median survival of 2.6 years and a 10-year survival rate of 13%. A rare variant is respiratory-onset ALS that accounts for about 3% of all cases of ALS, in which the initial symptoms are difficulty breathing with exertion, at rest, or while lying down.

Primary lateral sclerosis accounts for about 5% of all cases of ALS and affects upper motor neurons in the arms and legs.

There is no consensus among neurologists on the exact definition of familial ALS. The strictest definition is that a person with ALS must have two or more first-degree relatives who also have ALS. A less strict definition is that a person with ALS must have at least one first-degree or second-degree relative who also has ALS. Familial ALS is usually said to account for 10% of all cases of ALS, though estimates range from 5% to 20%. Higher estimates use a broader definition of familial ALS and examine the family history of people with ALS more thoroughly.

More than 20 genes have been associated with familial ALS, of which four account for the majority of familial cases: C9orf72, SOD1, FUS, and TARDBP. The genetics of familial ALS are better understood than the genetics of sporadic ALS; as of 2016, the known ALS genes explained about 70% of familial ALS and about 15% of sporadic ALS. Overall, first-degree relatives of an individual with ALS have a 1% risk of developing ALS. ALS has an oligogenic mode of inheritance, meaning that mutations in two or more genes are required to cause disease.

In 1956 the variant of ALS endemic to Guam was named “Amyotrophic lateral sclerosis/parkinsonism dementia complex”, as it had the typical symptoms of ALS accompanied by parkinsonism-like symptoms; the name in the local language is lytico-bodig disease.

In the United States and continental Europe, the term ALS refers to all forms of the disease, including “Classical” ALS, progressive bulbar palsy, progressive muscular atrophy, and primary lateral sclerosis.

Post Idea #11: Wavelength-division multiplexing

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Wavelength Division Multiplexing

Wavelength division multiplexing is a technique of multiplexing multiple optical carrier signals through a single optical fiber channel by varying the wavelengths of laser lights.

In WDM, the optical signals from different sources or are combined by a multiplexer, which is essentially an optical combiner.

The combined signal is transmitted via a single optical fiber strand.

The following diagram conceptually represents multiplexing using WDM. It has 4 optical signals having 4 different wavelengths.

Each of the four senders generates data streams of a particular wavelength.

The optical combiner multiplexes the signals and transmits them over a single long-haul fiber channel.

Categories of WDM. Based upon the wavelength, WDM can be divided into two categories .

Wavelength-Division Multiplexing

Entrance of Wavelength Division MultiplexingThe use of wavelength division multiplexing offers a further boost in fiber transmission capacity.

In an optical system this interference may arise from the fact that the center wavelength of laser diode sources and the spectral operating characteristics of other optical components in the link may drift with temperature and time, thereby giving rise to the need for a guard band between wavelength channels.

Since WDM is essentially frequency division multiplexing at optical carrier frequencies, the ITU developed DWDM standards that specify channel spacings in terms of frequency.

While greater capacities and spectral efficiencies are likely to be reached with current technologies, there is potential economic interest in reducing the number of wavelength channels by increasing the channel rate.

To meet the general requirement of 40-Gb/s downstream capacity, an underlying hybrid time and wavelength division multiplexing scheme is adopted in NG-PON2, giving rise to the time and wavelength division multiplexing PON. Fig.

Several wavelength pairs are multiplexed into a single PON system, whereby each wavelength is shared between multiple ONUs by employing time division multiplexing and multiple access mechanisms.

There are a number of multiplexing techniques, such as space division multiplexing, wavelength division multiplexing, and optical time division multiplexing, that are currently being applied to effectively utilize the bandwidth of optical fiber as a means to overcome the bandwidth bottleneck imposed by electrical time division multiplexing.

Wavelength-Division Multiplexing

In fiber-optic communications, wavelength-division multiplexing is a technology which multiplexes a number of optical carrier signals onto a single optical fiber by using different wavelengths of laser light.

Dense wavelength division multiplexing refers originally to optical signals multiplexed within the 1550 nm band so as to leverage the capabilities of erbium doped fiber amplifiers, which are effective for wavelengths between approximately 1525-1565 nm, or 1570-1610 nm.

Each wavelength-converting transponder receives an optical data signal from the client-layer, such as Synchronous optical networking [SONET /SDH] or another type of data signal, converts this signal into the electrical domain and re-transmits the signal at a specific wavelength using a 1,550 nm band laser.

As stated above, wavelength-converting transponders served originally to translate the transmit wavelength of a client-layer signal into one of the DWDM system’s internal wavelengths in the 1,550 nm band.

In the mid-1990s wavelength converting transponders rapidly took on the additional function of signal regeneration.

Dense WDM Transceivers: Channel 17 to Channel 61 according to ITU-T. Transponder In practice, the signal inputs and outputs will not be electrical but optical instead. This means that in effect wavelength converters are needed instead, which is exactly what a transponder is.

A transponder can be made up of two transceivers placed after each other: the first transceiver converting the 1550 nm optical signal to/from an electrical signal, and the second transceiver converting the electrical signal to/from an optical signal at the required wavelength.

What Is WDM? Wavelength Division Multiplexing

The vision of Smartoptics WDM is to make this happen in the most simple and cost effective way possible.

Organizations thrive on communication-a flow of data that runs between divisions and people that power progress.

Fiber optic cables are roads that carry information from office to office, site to site, country to country.

Using a fiber optic cable as a single lane road is wasteful.

Smartoptics solutions allow this road to be used as a multi-lane highway capable of transporting up to 80 simultaneous traffic channels together at once.

Smartoptics offers a way to “Add lanes” through intelligent WDM networking.

What Is Wavelength-Division Multiplexing And Its Benefits?

The simultaneous transmission of multiple optical channels on a fiber propagating in one direction is known as dual-fiber Unidirectional WDM. There are separate wavelengths that convey different paths across an optical fiber.

Bidirectional WDM is the simultaneous transmission of optical channels in both directions on a fiber, with the wavelengths employed segregated to achieve full-duplex communication between the two sides.

Transceivers, WDM wavelength division multiplexers, patch cords, and dark fiber components make up the basic WDM system.

It allows an optical fiber’s transmission capacity to multiply a single wavelength.

Each wavelength is independent of the others and does not interfere with each other when transmitting signals with diverse qualities such as pictures, data, and sound to ensure transmission transparency.

Large-capacity long-distance transmission can conserve optical fibers and 3R regenerators, lowering transmission costs dramatically.

The up/down and cross-connection of various telecommunication services can be implemented by altering and adjusting the wavelength of the optical signal on the optical path.

Wavelength Division Multiplexing (WDM)is a technology that multiplexes a number of optical carrier signals onto a single optical fiber by using different wavelengths of laser light.

Types of WDM.According to different wavelength, transmission distance, channel spacing and frequent stability, Wavelength Division Multiplexing can generally be divided into two types, Coarse Wavelength Division Multiplexing and Dense Wavelength Division Multiplexing.

Extended from wavelength division multiplexing(WDM), Coarse Wavelength Division Multiplexing is used to increase the bandwidth of an optical fiber by multiplexing several wavelength onto it.

Dense Wavelength Division Multiplexing is designed for long-haul transmission where wavelengths are packed tightly together in order to increase bandwidth over existing fiber networks.

DWDM uses much more than 18 channels with wavelength for a much wider channel spacing compared to CWDM. DWDM works by combining and transmitting multiple signals simultaneously at different wavelengths on the same fiber.

First, high-precision filters are required to peel away one specific wavelength without interfering with neighboring wavelengths.

Wavelength Division Multiplexing is a technology that multiplexes a number of optical carrier signals onto a single optical fiber.

Post Idea #12: Reconfigurable optical add-drop multiplexer

Related Articles – Summarized

Definition From WhatIs.Com

A reconfigurable optical add-drop multiplexer is a device that can add, block, pass or redirect modulated infrared and visible light beams of various wavelengths in a fiber optic network.

Before the development of optical multiplexing devices such as ROADMs, signal routing in fiber optic networks was done by converting the IR or visible beams to electrical signals and routing those signals using conventional electronic switches.

The rerouted electrical signals were then converted back into IR or visible beams.

An outgoing IR or visible beam can be generated or an incoming beam terminated.

A beam can also be passed through the device without modification.

Then the data is impressed onto a beam of another wavelength.

Neither the WB nor the PLC ROADM designs facilitate true optical branching, in which beams of any wavelength can be directly routed to any desired port without the need to perform multiple intermediate operations.

Reconfigurable Optical Add/Drop Multiplexer

WSS ROADM – PL-1000RO. The solution offers highly flexible wavelength routing capabilities suitable for mesh, ring, linear add/drop, core and edge DWDM network topologies.

The PL-1000RO ROADM is configured dynamically to add/drop selected wavelengths at any node in the network and seamlessly change the network node capacity as needed.

The product integrates an EDFA for amplifying the wavelengths and a tunable dispersion compensation module for delivering effective and flexible wavelength routing.

The PL-1000RO ROADM simplifies network management and reduces operation costs by allowing fast deployment of new wavelengths remotely.

Offers highly flexible wavelength routing capabilities suitable for mesh, ring, linear add/drop, core and edge DWDM network topologies.

Enables simple network management and reduces operation costs by allowing deployment of new wavelengths remotely.

User-friendly NMS to deploy new services, control and monitor the optical network.

Edu Abstract: We show how a spatial mode can be extracted from a light beam, leaving the other orthogonal modes undisturbed, and allowing a new signal to be retransmitted on that mode.

Recently, there has been growing interest in exploiting spatial modes in fibers [2-21] and in free-space communications , especially with multiple overlapping modes and including angular momentum beams [22-24]. It is now possible with MIMO techniques to separate signals on different spatial modes if the mode can be spatially sampled onto different coherent detectors, but such an approach requires significant digital signal processing and does not allow one signal to be dropped or added without effectively measuring all the spatial channels.

As in the self-aligning mode coupler and its extensions and in related work that establishes the orthogonal set of modes for any linear optical system , this method can automatically select the mode of interest, and requires no calculations.

At least for modes that do not couple during propagation, for short links of low dispersion, or for modes or mode groups with low differential group delay, this kind of approach may allow arbitrary add and drop of different spatial optical channels without the necessity of MIMO calculations.

For fibers in which there is negligible mode coupling during propagation, such as short multimode fibers using their lowest modes or short fewmode fibers, the mode shapes to be separated will not be changing.

Then power in other orthogonal modes would be ignored by these detectors, allowing the feedback loops to operate on the desired add-drop mode even in the presence of other modes.

Detectors D11 – D13 can be set to look for the low-frequency modulation of the first mode, D21 – D22 to look for the low-frequency modulation of the second mode, and D31 for the low-frequency modulation of the third mode.

What Is Reconfigurable Optical Add-Drop Multiplexer

In the fiber optic network which uses wavelength division multiplexing, reconfigurable optical add-drop multiplexer is used to remotely add, block, pass or redirect modulated light emissions-infrared and visible-within a range of wavelengths.

The different switching technologies in ROADM devices include microelectronic mirrors, live view screen, thermo-optic and beam-steering switches in planar waveguide circuits, and tunable optical filters.

Within the ensuing years, ROADM devices have brought bandwidth flexibility and operational efficiency to networks.

ROADM-based networks are enabling an automated optical layer with dynamic multipoint connectivity, independent wavelength add-drop, remote bandwidth allocation that has been enhanced power management capabilities.

The need to measure optical loss per channel for multiple ROADM configurations.

Compliance using the optical transport network standard-ITU-T G.709 standard.

Unlike the optical add-drop multiplexer, Capabilities of ROADM test equipment should encompass optical spectrum analysis, and OTN performance qualifiers for newly commissioned links, along with the transport layer and all ROADM-supported interfaces.

A Flexible And Reconfigurable Optical Add-Drop Multiplexer For Mode Division Multiplexing Systems

Abstract: Reconfigurable optical add-drop multiplexer is one of the key building blocks for on-chip optical networks, which can download the desired signals from the bus waveguide to the corresponding drop port and upload the local signals from the add port to the bus waveguide to achieve the signals dropping/adding between the local and the bus waveguide.

In this letter, we propose a ROADM based on a Benes network for mode-division multiplexing systems.

As a proof of the concept, a ROADM with three quasi-transverse electric modes is fabricated and experimentally demonstrated, which can download signals from TEi mode channel in the bus waveguide to an arbitrary local drop port or upload local signals to TEi mode channel via an arbitrary add port.

The excess loss of the fabricated device is less than 10.7 dB, and the crosstalk among different space or mode channels is lower than -13.7 dB. Finally, a 12 Gbps data transmission experiment is carried out to verify the performance of the device.

The proposed device is reconfigurable and scalable, and thus, it is expected to be used for optical data processing in the mode-division multiplexing systems.

Reconfigurable Optical Add-Drop Multiplexer

In fiber optics, a reconfigurable optical add-drop multiplexer is a form of optical add-drop multiplexer that adds the ability to remotely switch traffic from a wavelength-division multiplexing system at the wavelength layer.

This allows individual or multiple wavelengths carrying data channels to be added and/or dropped from a transport fiber without the need to convert the signals on all of the WDM channels to electronic signals and back again to optical signals.

The planning of entire bandwidth assignment need not be carried out during initial deployment of a system.

The configuration can be done as and when required without affecting traffic already passing the ROADM. ROADM allows for remote configuration and reconfiguration.

In ROADM, as it is not clear beforehand where a signal can be potentially routed, there is a necessity of power balancing of these signals.

ROADM functionality originally appeared in long-haul dense wavelength division multiplexing equipment, but by 2005, it began to appear in metro optical systems because of the need to build out major metropolitan networks in order to deal with the traffic driven by the increasing demand for packet-based services.

The switching or reconfiguration functions of a ROADM can be achieved using a variety of switching technologies including microelectromechanical systems, liquid crystal, thermo optic and beam-steering switches in planar waveguide circuits, and tunable optical filter technology.

Post Idea #13: Dominion Voting Systems

Related Articles – Summarized

Dominion Voting Systems: 5 Fast Facts You Need To Know

Dominion Voting Systems is an election services company from Canada that is responsible for the technology used to count votes in many of the close battleground states in the 2020 presidential election.

Dominion Voting Systems is a company from Toronto, Canada, that has headquarters in Denver, Colorado, and is one of three major firms providing voting machines in U.S. elections.

President Donald Trump has also made claims against Dominion, writing on Twitter, “Report: Dominion deleted 2.7 million Trump votes nationwide. Data analysis finds 221,000 Pennsylvania votes switched from President Trump to Biden. 941,000 Trump votes deleted. States using Dominion Voting Systems switched 435,000 votes from Trump to Biden.” He provided no evidence.

“The industry has a two-tier structure with the three top-tier vendors, Election Systems and Software, Hart Intercivic, and Dominion Voting Systems covering approximately 92% of the total eligible voter population,” a major 2017 study on voting companies by the Penn Wharton Public Policy Initiative said.

In January 2020, Poulos said in a written statement to the U.S. House that he was the “Chief executive officer and co-founder of Dominion Voting Systems. As a U.S.-owned company, we currently provide voting systems and services to jurisdictions across 30 states and Puerto Rico.”.

According to Bloomberg, Dominion Voting Systems “Hired a high-powered firm that includes a longtime aide to Speaker Nancy Pelosi. Dominion’s first-ever lobbying firm is Brownstein Farber Hyatt and Schreck. Nadeam Elshami, Pelosi’s former chief of staff, is one of the lobbyists on the account.”

According to Business Insider, Georgia “Became the only state in the country last year to overhaul its entire election system, paying Denver-based Dominion Voting Systems $106 million for new voting machines, printers and scanners.”

Dominion Voting Systems Gets Reprieve As Pennsylvania Court Halts Machine Inspection

Pennsylvania’s Supreme Court on Friday issued a temporary halt to an inspection of Dominion voting machines in the state’s Fulton County just before the inspection was set to begin.

The decision came in response to a decision from a lower court in which a state judge declined to halt what Republican state lawmakers call a “Forensic investigation” of the state’s election equipment, according to the Associated Press.

The lower court rejected requests filed last week from attorneys representing Governor Tom Wolf and Dominion Voting Systems to establish strict protocols over who is allowed to inspect the voting machines.

The requests made last week stated that Dominion and state officials wanted the investigation to be halted unless it could be completed by an accredited elections inspector, according to the Pennsylvania Capital-Star.

Wolf’s administration and Dominion first objected to the idea of the voting machine inspection last month, according to the AP. Last July, the election machines used in Fulton County were decertified by acting Pennsylvania Secretary of State Veronica Degraffenreid after county officials allowed the machines to be inspected by Wake TSI, a separate software company, the AP reported.

The inspection was set to begin in a meeting that started at 1 p.m. Friday before Tom Breth, another attorney for the county, announced to those assembled that the state Supreme Court had halted the investigation, the AP added.

Dominion Voting Systems did not immediately respond to a request for comment.

The ballot contained 14 contests: 1 straight party contest, 1 vote for a pair, 7 vote for one, 2 vote for not more than three, 1 vote for not more than five, 1 referendum contest and 1 retention contest.

A closed primary election consisting of two political parties, three precincts Precinct 1, Precinct 2 – split into Precinct 2a and 2b, Precinct 3, was run utilizing EMS, ICX, ICP and ICC. For the Republican ballot, there were 21 contests: 19 partisan contests and 2 referendums, 10 “Vote for One”, 1 “Vote for no more than Two”, 3 “Vote for no more than Three”, 4 “Vote for no more than Four” and 1 “Vote for no more than Fifteen”.

For the Democratic ballot, there were 21 contests: 19 partisan contests and 2 referendums, 11 “Vote for One”, 1 “Vote for no more than Two”, 1 “Vote for no more than Three”, 5 “Vote for no more than Four” and 1 “Vote for no more than Fifteen”.

The Functional Examiner thus concluded that the system is in compliance with Section 1107A(2), 25 P.S. 3031.7(2). Each of the applicable components of Democracy Suite 5.5 allowed the test voter to cast votes for candidates on the ballot and also a write-in vote, demonstrating compliance with Section 1107-A(5), 25 P.S. 3031.7(5). Democracy Suite 5.5 meets the requirements for Section 1107-A(6), 25 P.S. 3031.7(6), because the test voters cast votes on different ballot styles for candidates and questions and the ICX displayed only contests for which the voter was entitled to vote.

A closed primary election consisting of two political parties, three precincts (Precinct 1, Precinct 2 – split into Precinct 2a and 2b, Precinct 3 was run utilizing EMS, ICX, ICP and ICC. For the Republican ballot, there were 21 contests: 19 partisan contests and 2 referendums, 10 “Vote for One”, 1 “Vote for no more than Two”, 3 “Vote for no more than Three”, 4 “Vote for no more than Four” and 1 “Vote for no more than Fifteen”.

The mandate requires counties using central count paper-based systems to develop voting system specific voter education programs that inform voters of the effect of over voting, and instruct voters on how to correct a ballot before it is cast, including instructions on obtaining a replacement ballot.

As a voter approaches the voting station, poll workers can help voters adjust the voting system or attach personal assistive technology:  Help voters get positioned at the voting system so they can reach all controls.

After Court Lets Fox News Challenge Move Forward, Here’S Where Dominion And Smartmatic’S Defamation Suits Stand Now-And Who Could Be Next

Voting company Smartmatic’s defamation lawsuit against Fox News can move forward-but challenges against other defendants including Sidney Powell cannot-a judge ruled Tuesday, as Smartmatic and Dominion Voting Systems pursue 11 defamation lawsuits over baseless election fraud claims about their voting machines.

New York Supreme Court Justice David B. Cohen ruled Smartmatic’s $2.7 billion lawsuit against Fox News can move forward-as well as its claims against anchors Lou Dobbs and Maria Bartiromo-after Smartmatic sued them in February 2021, alleging the defendants “Engaged in a conspiracy to spread disinformation about Smartmatic.”

Cohen dismissed Smartmatic’s allegations against far-right attorney Sidney Powell and Fox anchor Jeanine Pirro, and dismissed some claims against attorney Rudy Giuliani but let others move forward.

Smartmatic also sued One America News Network in federal court and Newsmax in Delaware state court in November, alleging both networks “Reported a lie” and spread fraud claims about the company-whose machines were only used in California in 2020-knowing they were false; those lawsuits and Lindell’s suit are still pending.

Dominion sued Fox News in March alleging the network had knowingly spread false news about its machines to improve failing ratings, and a Delaware state judge denied Fox’s motion to dismiss the case in December.

Dominion sued OANN and anchors Chanel Rion and Christina Bobb in federal court and Newsmax in Delaware state court in August, alleging the two far-right networks promoted fraud allegations on their network knowing they were false and “helped create and cultivate an alternate reality where up is down, pigs have wings, and Dominion engaged in a colossal fraud to steal the presidency from Donald Trump by rigging the vote.

That’s approximately how much Dominion is asking for in damages against Byrne, OANN, Newsmax and Fox News.

Here’S What Was Discovered About Dominion Machines Used In A Swing State

Judge Kevin Elsenheimer of the 13th Circuit Court on Monday ordered a “Forensic imaging” of the Dominion Voting Systems machines and software used in Antrim County, Michigan, where 6,000 votes for President Trump were incorrectly attributed to former Vice President Joe Biden.

“It is critical to understand that the Dominion system classifies ballots into two categories, 1) normal ballots and 2) adjudicated ballots. Ballots sent to adjudication can be altered by administrators, and adjudication files can be moved between different Results Tally and Reporting terminals with no audit trail of which administrator actually adjudicates the ballot batch,” the report states.

Dominion Voting Systems has repeatedly denied there are issues with their voting machines or that their software could be used to swap votes from one candidate to another.

Dominion voting machines do one thing: accurately tabulate votes from county-verified voters using a durable paper ballot controlled and secured by local elections officials.

During testimony in front of the Michigan Senate Oversight Committee on Tuesday, Poulos stated the goal of his company isn’t to run elections but to provide machines to election officials so they can carry out their duty.

“We do not run elections. Our role is limited to providing local election offices with the machines they need to run elections. After election officials have determined who is eligible to vote, we provide machinery for voters to mark their ballot and for election officials to tally the count,” he explained in his opening statement.

Poulos and other Dominion surrogates have defended their systems, saying votes made on the machines can be cross compared to paper ballots.

‘Online And Vulnerable’: Experts Find Nearly Three Dozen U.S. Voting Systems Connected To Internet

While the voting machines themselves are not designed to be online, the larger voting systems in many states end up there, putting the voting process at risk.

“We found over 35 had been left online and we’re still continuing to find more,” Kevin Skoglund, a senior technical advisor at the election security advocacy group National Election Defense Coalition, told NBC News.”We kept hearing from election officials that voting machines were never on the internet,” he said.

“And we knew that wasn’t true. And so we set out to try and find the voting machines to see if we could find them on the internet, and especially the back-end systems that voting machines in the precinct were connecting to to report their results.”

The three largest voting manufacturing companies – Election Systems &Software, Dominion Voting Systems and Hart InterCivic – have acknowledged they all put modems in some of their tabulators and scanners.

The 35 systems Skoglund’s team found represent a fraction of total voting systems nationwide, though he believes they only captured a portion of the systems that are or have been online.

“Once a hacker starts talking to the voting machine through the modem, the hacker cannot just change these unofficial election results, they can hack the software in the voting machine and make it cheat in future elections,” he said.

While the company’s website states that “Zero” of its voting tabulators are connected to the internet, ES&S told NBC News 14,000 of their DS200 tabulators with online modems are currently in use around the country.

Dominion Voting Systems

Dominion Voting Systems Corporation is a company that sells electronic voting hardware and software, including voting machines and tabulators, in the United States and Canada.

Dominion Voting Systems sells electronic voting systems hardware and software, including voting machines and tabulators, in the United States and Canada.

In 2019, the state of Georgia selected Dominion Voting Systems to provide its new statewide voting system beginning in 2020.

51 of the province’s municipalities had their elections impacted when the company’s colocation centre provider imposed an unauthorized bandwidth cap due to the massive increase in voting traffic in the early evening, thus making it impossible for many voters to cast their vote at peak voting time.

Following the 2020 United States presidential election, Donald Trump, his attorneys and other right-wing personalities amplified the canard originated by the proponents of the far-right QAnon conspiracy theory that Dominion Voting Systems had been compromised, resulting in millions of votes intended for Trump either being deleted or going to rival Joe Biden.

There is no evidence for any of these claims, which have been debunked by various groups including election technology experts, government and voting industry officials, and the CISA. On November 12, 2020, CISA released a statement that confirmed “There is no evidence that any voting system deleted or lost votes, changed votes or was in any way compromised.” The statement was signed by various government and voting industry officials including the presidents of the National Association of State Election Directors and the National Association of Secretaries of State.

After questions about the reliability of the company’s systems surfaced during the election, Edward Perez, an election technology expert at the Open Source Election Technology Institute stated, “Many of the claims being asserted about Dominion and questionable voting technology is misinformation at best and, in many cases, they’re outright disinformation.”

Post Idea #14: Electronic Arts

Related Articles – Summarized

Electronic Arts Home Page

Celebrating the positive power of connecting through play.

Learn all about the latest games and rewards now available with your EA Play membership.

Learn about FUT Birthday and see the squad and their ratings in FIFA 22 Ultimate Team.

Learn about Road to the Final and see the squad and their ratings in FIFA 22 Ultimate Team.

Learn about VOLTA ARCADE and the games you can play in VOLTA FOOTBALL in FIFA 22.

Learn about Future Stars Swaps and how to earn them in FIFA 22 Ultimate Team.

To inspire the world to play, we must design stories, characters, experiences and services that resonate with all players.

Electronic Arts

Electronic Arts Inc. is an American video game company headquartered in Redwood City, California.

282  In 1990, Electronic Arts began producing console games for the Nintendo Entertainment System, after previously licensing its computer games to other console-game publishers.

Electronic Arts dropped its support for 3DO in favor of the PlayStation, 3DO’s production ceased in 1996 and, for the remainder of the company’s lifetime, 3DO developed video games for other consoles and the IBM PC until it folded in 2003.

Early in 1997, Next Generation identified Electronic Arts as the only company to regularly profit from video games over the past five years, and noted it had “a critical track record second to none”.

On February 2, 2009, Ludlum Entertainment had inked a deal with Electronic Arts to grant exclusive rights to bring the work of Robert Ludlum into video gaming.

First introduced in 1991 as the Electronic Arts Sports Network, before being renamed due to a trademark dispute with ESPN, EA Sports publishes all the sports games from EA, including FIFA Football, Madden NFL, Fight Night, NBA Live, NCAA Football, Cricket, NCAA March Madness, Tiger Woods PGA Tour, NHL, NASCAR and Rugby.

EA Originals is a program within Electronic Arts to help support independently developed video games.

Electronic Arts Is Not Hosting An EA Play Live Event This Year

We don’t exactly have a solid list of events for the year.

If you were expecting Electronic Arts to return with an EA Play Live 2022, then we have some unfortunate news.

“We love EA Play Live as it’s our way of connecting with our players and sharing what’s new with all of you,” EA told IGN. “However, this year things aren’t lining up to show you everything on one date. We have exciting things happening at our world-class studios and this year we’ll reveal much more about these projects when the time is right for each of them. We look forward to spending time with you throughout the year!”.

Since 2020, EA has hosted its EA Play Live in lieu of E3. During that tumultuous year, the ESA decided to cancel the typically in-person E3, leaving publishers to showcase games in their own events.

With EA Play Live 2020, the company revealed games like Lost in Random and Star Wars: Squadrons.

EA is skipping the whole Play Live business altogether.

So long as we can avoid the half-dozen or so game events in a single year.

Electronic Arts Cancels EA Play Live 2022

Electronic Arts will not be holding an EA Play Live event during 2022, the publisher announced this week.

The annual EA Play Live event typically takes place during the summer amid things like E3 and the rest of the big gaming events, but EA has opted instead to not hold one central event where its announcements will be shared.

The confirmation of EA Play Live’s cancellation was shared by an EA representative in a statement to IGN. The publisher said it loved how EA Play Live connected the community but said that things weren’t “Lining up” to hold the event this year.

“We love EA Play Live as it’s our way of connecting with our players and sharing what’s new with all of you,” the statement said.

EA had not been hyping up its EA Play Live event for 2022 or anything of that nature, but the return of the event was an expected one since it’s taken place in past years whether in-person or via an online format.

This event is the same one previously known simply as EA Play but was rebranded to EA Play Live after the publisher’s subscription service adopted the former as its name.

No big event to look forward to means it’s harder to pinpoint when we’ll hear about those sorts of games, but the summer will hopefully still bring news about EA’s projects even if the central event isn’t happening.

Electronic Arts Isn’T Hosting Its Traditional EA Play Live Event In 2022

Electronic Arts has confirmed it won’t be holding its traditional EA Play Live event in 2022.

Rather than host a major product showcase event this summer, the company looks set to spread its game reveals throughout the year.

“An EA spokesperson told IGN:”We love EA Play Live as it’s our way of connecting with our players and sharing what’s new with all of you.

Last year’s EA Play Live, which took place in July, was used to show off titles including Battlefield 2042 and Apex Legends, and to announce the recently released Grid Legends and the upcoming Dead Space remake.

From 2016-2020, EA Play was held in conjunction with June’s E3 event.

E3 has cancelled this year’s physical show for the third year running and is yet to confirm plans for a digital event.

The Game Awards founder Geoff Keighley has confirmed his digital event Summer Game Fest will take place as planned this year, likely in June.

Electronic Arts Inc. Stock Position Cut By M&G Investment Management Ltd.

M&G Investment Management Ltd. decreased its holdings in shares of Electronic Arts Inc. by 13.6% in the 4th quarter, HoldingsChannel.com reports.

M&G Investment Management Ltd.’s holdings in Electronic Arts were worth $23,598,000 at the end of the most recent reporting period.

Carolinas Wealth Consulting LLC lifted its position in shares of Electronic Arts by 147.1% in the second quarter.

Herold Advisors Inc. bought a new position in Electronic Arts during the third quarter valued at approximately $42,000.

Finally, JFS Wealth Advisors LLC bought a new position in Electronic Arts during the third quarter valued at approximately $49,000.

Electronic Arts had a return on equity of 18.59% and a net margin of 9.83%. Electronic Arts’s revenue for the quarter was up 7.4% compared to the same quarter last year.

The ex-dividend date is Tuesday, March 8th. This represents a $0.68 annualized dividend and a yield of 0.55%. Electronic Arts’s dividend payout ratio is currently 30.63%. About Electronic Arts.

Polygon Studios Adds C-Suite And VP-Level Talent From Amazon, Electronic Arts, Penske Media

Development company focused on Ethereum sidechain Polygon.

Has hired six executives from prominent tech and gaming companies like Amazon, Electronic Arts, and Riot Games.

Michael Blank from Electronic Arts is joining Polygon Studios as chief operating officer, and Young Ko is joining as chief financial officer from Penske Media, which includes among its brands Variety and Rolling Stone.

Urvit Goel and Charnjit Bansi also are joining Polygon Studios, as VP of gaming business development and VP of game design, respectively.

Bansi worked at Mythical Games, and before that at Call of Duty developers Infinity Ward and Sledgehammer Games.

Ben Watley, another gaming industry executive joining Polygon Studios from Electronic Arts, will focus on gaming strategy along with fellow new hire Will Matteson, who previously worked at NASA as a software engineer and Riot Games as a strategist.

Who joined the company less than two months ago after leading YouTube’s Gaming division, said he’s “Thrilled” with the hires.

Post Idea #15: Merchant cash advance

Related Articles – Summarized

Merchant Cash Advance Guide For 2022

Business owners receive funds as a lump sum upfront from a merchant cash advance provider and repay the advance with a percentage of the business’ sales.

American Express Merchant Financing Not technically a merchant cash advance, American Express Merchant Financing is a short-term loan for businesses that accept American Express credit card payments.

A merchant cash advance provider will provide an approved amount, and the merchant will repay the advance with a percentage of each day’s credit card sales.

The amount and number of your credit card transactions are more important than a business’ credit profile, putting less emphasis on personal and business credit information-solid sales numbers can help a business with poor credit qualify for a merchant cash advance.

A Merchant Cash Advance provider is typically more interested in the amount of credit card transactions your business processes each day, so they are often willing to work with businesses that have a less-than-perfect credit profile.

Although there are a number of factors that make an MCA attractive to a business with a weak credit profile, and there are many businesses that use this type of financing to augment a short-term cash flow crunch, a good use for a merchant cash advance is to fund a short-term opportunity to generate additional ROI on a project-like the purchase of quick-turnaround inventory.

Different from a merchant cash advance in that it is based on your cash flow, has a fixed payment, and will likely include a lower interest rate than a typical merchant cash advance.

A merchant cash advance is a type of business financing in which a company advances you a lump sum that you repay via a percentage of your daily credit card and debit card sales, plus a fee.

Merchant cash advances are usually easy to qualify for and fund quickly; however, they’re known for high APRs-and because they’re not actually business loans, there’s little regulation around merchant cash advances.

Because MCA providers can plug-in to your bank account or merchant service provider, merchant cash advances are easy-to-access, fast to fund products.

As we’ve mentioned, merchant cash advances are expensive-and therefore, it’s important to understand how MCA financing companies charge fees.

Suitable for a range of business purposes: Overall, a merchant cash advance can be used to fund essentially any business purpose.

Daily deduction of credit card sales reduces cash flow: Again, although a benefit of merchant cash advances is that payments vary based on your sales, the actual structure of an MCA makes it difficult on a business’s cash flow.

In general you’ll want to consider any and all alternative funding options you have before turning to an MCA. As we’ve discussed at length throughout this guide, a merchant cash advance will be one of the most expensive forms of financing out there-with APRs that can reach over 100%. Therefore, before you look into merchant cash advance companies, start your funding search with some of the options we’ve mentioned, like short-term loans or business lines of credit.

Merchant Cash Advance

A merchant cash advance or business cash advance is a form of business financing in which a lump-sum payment is given to a business in exchange for an agreed-upon percentage of future revenues or credit card sales.

Merchant cash advances typically have shorter payment terms and smaller regular payment amounts than business installment loans.

Merchant cash advances are friendly for business owners with lower credit, because credit scores are not as important as sales projections when determining eligibility.

Is a Merchant Cash AdvanceRight for Me? Merchant cash advances are suitable for a wide range of businesses, such as restaurants or retail shops whose revenue comes primarily from credit card sales.

The rates on merchant cash advances are typically higher than other types of alternative business loans.

These costs may lead to a debt cycle for some businesses if they have to refinance into another business cash advance in order to repay the debt, which can cause cash-flow problems or put them at risk of default.

Before turning to a merchant cash advance, small business owners can seek out alternatives, such as a flexible line of credit from Headway Capital.

Merchant Cash Advance

Funding Circle and our network of partner lenders are here to help you navigate through the confusing world of Merchant Cash Advances.

Merchant cash advances can be a good fit for small businesses that are seasonal or have fluctuating revenue and want to inject funds into their business.

This could be a good option for small businesses needing a cash advance while still working on their credit health.

Cons.Daily payments can make cash flow harder to predict compared to other financing options.

Apply nowTackle an emergencyGet quick cash to cover the unexpected, cash flow gaps or to replace critical equipment.

Learn more about how merchant cash advances work, the pros and cons of this financing option, and more in this complete guide.

In this guide, you’ll learn how to translate factor rates to APRs.Learn moreMerchant cash advances, term loans, lines of credit, what does it all mean? Read this comprehensive guide to learn more about the most popular types of small business financing.

Merchant Cash Advance: A Complete Guide For 2021 – AdvisorSmith

A merchant cash advance allows your business to exchange your future earnings for immediate cash.

With MCAs, you receive a lump sum of cash from a merchant cash advance provider, which you pay back using a percentage of your daily sales.

After obtaining a merchant cash advance, your business will receive a lump sum cash advance very quickly, usually by direct deposit from your provider within just a few days.

In order to determine the total cost of your MCA, you simply multiply the total amount of cash advanced to you by the factor rate.

What are the benefits of a merchant cash advance? Fast cash: The approval process for MCAs is incredibly fast, and your business will likely begin receiving funds within a few days of submitting your application.

What are the drawbacks of a merchant cash advance? Expensive: MCAs are notoriously expensive.

This is not the case with MCAs, as they use factor rates rather than interest rates, meaning a set amount will be owed no matter how quickly you pay back the cash advance.

Merchant Cash Advance: 1400+ 5 Star Reviews

A Merchant Cash Advance is sometimes referred to as a “Business Cash Advance,” “Credit Card Factoring,” or a “Credit Card Processing Loan.” A business owner will receive a lump sum paid back via a fixed percentage of future daily credit card sales.

The amount of business financing you qualify for from merchant cash advance companies depends on the amount of future credit card receivables or the sales you make to customers using a credit card payment.

The capital is distributed almost immediately from the merchant cash advance provider instead of waiting weeks/months to get the full amount from the credit card processing company.

The size of your borrowing amount and your merchant cash advance terms depend primarily on your previous and anticipated monthly credit card sales volume.

Your business credit profile does impact several other elements of your merchant cash advance loan.

If you paid off the entire advance in six months, your APR would be at least 60%. If you repay the advance agreed upon in twelve months, your APR would likely be closer to 30%. What Are The Disadvantages of Merchant Cash Advances?

Borrowers with subpar fico scores and cash flow problems are statistically less likely to pay off the merchant cash advance on time.

Merchant Cash Advance

A merchant cash advance was originally structured as a lump sum payment to a business in exchange for an agreed-upon percentage of future credit card and/or debit card sales.

Merchant cash advance companies provide funds to businesses in exchange for a percentage of the businesses’ daily credit card income, directly from the processor that clears and settles the credit card payment.

Merchant cash advance transactions are not subject to state usury laws that limit lenders from charging high-interest rates.

On 10 June 2016, a New York Supreme Court judge presiding over a published merchant cash advance case ruled that “If the transaction is not a loan, there can be no usury,” adding also that asking the court to convert an agreement to sell future receivables into a loan agreement “Would require unwarranted speculation.”

Payments to the merchant cash advance company fluctuate directly with the merchant’s sales volumes, giving the merchant greater flexibility with which to manage their cash flow, particularly during a slow season.

Small businesses that don’t have the cash on hand to fund an expansion by themselves could rely on external funding, such as a merchant cash advance.

Midsize or small business owners who cannot qualify for traditional business loans have the ability to secure a Merchant Cash Advance.

Post Idea #16: Emulsifier

Related Articles – Summarized

Definition, Types, & Uses

Emulsifier, in foods, any of numerous chemical additives that encourage the suspension of one liquid in another, as in the mixture of oil and water in margarine, shortening, ice cream, and salad dressing.

A number of emulsifiers are derived from algae, among them algin, carrageenan, and agar.

Lecithins, such as those found in egg yolk, are also used as emulsifying agents.

The basic structure of an emulsifying agent includes a hydrophobic portion, usually a long-chain fatty acid, and a hydrophilic portion that may be either charged or uncharged.

The hydrophobic portion of the emulsifier dissolves in the oil phase, and the hydrophilic portion dissolves in the aqueous phase, forming a dispersion of small oil droplets.

Emulsifiers thus form and stabilize oil-in-water emulsions, uniformly disperse oil-soluble flavour compounds throughout a product, prevent large ice-crystal formation in frozen products, and improve the volume, uniformity, and fineness of baked products.

Emulsifiers are closely related to stabilizers, which are substances that maintain the emulsified state.

What Is An Emulsifier?

When water and oil are mixed together and vigorously shaken, a dispersion of oil droplets in water – and vice versa – is formed.

When an emulsifier is added to the system, the droplets remain dispersed, and a stable emulsion is obtained.

An emulsifier consists of a water-loving hydrophilic head and an oil-loving hydrophobic tail.

The hydrophilic head is directed to the aqueous phase and the hydrophobic tail to the oil phase.

The emulsifier positions itself at the oil/water or air/water interface and, by reducing the surface tension, has a stabilising effect on the emulsion.

In addition to their ability to form an emulsion, emulsifiers have the ability to interact with other food ingredients.

The emulsifier may be an aerating agent, starch complexing agent and/or crystallisation inhibitor.

What Are Emulsifiers, And What Do They Do In Our Food?

Emulsifiers are Food and Drug Administration-approved food additives that help products containing immiscible food ingredients, like oil and water, to combine.

Hydrocolloids serve as thickening agents and support the structure, texture, flavor, and shelf life of various food products, and they are often referred to simply as gums because of the food texture and consistency they create.

Hydrocolloids, like xanthan gum, can also come from microbial sources, and even food products themselves-mustard, oil, salt, egg yolk and vinegar-can serve as emulsifiers.

Without emulsifiers like hydrocolloids, you could look forward to scooping into a layer of fat before getting to the soupy, water-based flavors of your yogurt-no thanks! Emulsifiers also reduce food stickiness and help foods maintain a smooth texture and flavor.

Guar gum can be used to emulsify, thicken, and stabilize ingredients in food products, even those that require cold temperatures during manufacturing.

Natural emulsifiers like hydrocolloids are present in many foods and are helpful in ensuring packaged foods keep their consistency, texture, smoothness, and flavor.

To help consumers identify foods containing these additives and make informed decisions, the FDA requires that food companies specify emulsifiers used in food products on their ingredient lists.

What Are The Common Food Emulsifiers?

Successful food manufacturing requires equipment like Ginhong mixers that will help mill, grind, reduce particle size, homogenize, disperse, and emulsify.

A food emulsifier acts as a bond that holds the particles of the ingredients altogether.

Water spattering in food preparation or cooking is also reduced by an emulsifier.

Now that we have understood the definition and functions of an emulsifier in processed foods, it’s time to jump into the enumerated and expounded common food emulsifiers.

For products like chocolates, it gives the sensation that feels like the food product is melting inside your mouth – adding the tastiness of the food.

These are the most used food emulsifiers from the early times until today.

Aside from holding the ingredients altogether, emulsifiers make the food you eat much more appealing in taste and in appearance.

What Are Emulsifiers And What Is Their Function In Food?

Even though their name might sound pretty chemical, emulsifiers have been used for a long period of time and the word emulsifier is simply used to cover a range of different components that all do a similar job: keep two components mixed that don’t want to be mixed.

Emulsifiers stabilize emulsions, so in order to understand an emulsifier, we should first introduce an emulsion.

Surface modifiers; these components will sit on the surface of the droplets floating through the continuous phase, preventing them from merging, for the rest of this post, we’ll call these emulsifiers.

I’ve come across cases where emulsifiers are all components that somehow stabilizes an emulsion.

There are a lot of different emulsifiers which are used in food.

Water-in-oil emulsifiers tend to have an HLB-value of 3-7 whereas those for oil-in-water emulsions tend to be higher, 8-16.

A good comparison between surfactants and proteins as emulsifiers.

ScienceDirect Topics

Food emulsifiers are created by alcoholysis or direct esterification of edible fatty acids taken from animal or vegetable sources with polyols.

MDGs are the most commonly used food emulsifiers, composing about 75% of total emulsifier production.

Stearoyl lactylates are the reaction products of stearic acid and lactic acid, which are further converted into the calcium or sodium salts and become calcium stearoyl-2-lactylate and SSL. SSL is one of the most common anionic emulsifiers used in the food industry.

Ammonium phosphatide, fatty acid salts, glycerol esters of wood resin, quillaia extract, and thermally oxidized soybean oil interacted with mono- and diglycerides of fatty acids are other approved emulsifiers.

Additives with emulsifying properties, which are mainly utilized as food humectants, stabilizers, thickeners, and/or sweeteners, are modified starches; lactic acid salts; ortho-, di-, tri-, or polyphosphoric acid salts; propylene glycol; polysaccharides; sugar alcohols; triacetin; and triethyl citrate.

Lecithin, modified starches, mono- and diglycerides of fatty acids, and esters of mono- and diglycerides of fatty acids are added in foods, excluding food for infants and young children, at levels in accordance with GMP. The rest of the emulsifiers are added at levels varying between 100 and 10.

3.4 Adverse effects related to the exposure of different food emulsifiersVarious studies suggest that food emulsifiers.

Post Idea #17: Companion robot

Related Articles – Summarized

Companion Robots Are Here. Just Don’T Fall In Love With Them

The arrival of Kuri and other companion robots means that in the near future, you’ll need to pay very close attention to how robots make you feel.

So makers of companion robots want users to have pleasant interactions and make it abundantly clear that robots are tools, not replacements for friends or family.

One day super-sophisticated robots will form complex bonds with humans.

That’s where the ethics of companion robots get sticky.

Our relationship to robots is wholly different than the relationship we have with, say, our pets.

Robots? Kuri can’t tell me it loves me back, because Kuri cannot love.

Robots touching humans sounds weird and, well, metallic.

Buy Real Sex Doll Robots In USA, Canada, Europe & Australia At An Affordable Price

Our sex robot doll is lifelike and provides a more realistic, personal and enjoyable experience than with typical sex dolls.

Our sex robot dolls are affordable and compare to AI sex doll robots that cost $10,000+.

Our lifelike AI sex robot doll can hold a non-sexual or sexual conversation with you.

Her responsive head, eyes, mouth and lip movements are so lifelike you will forget she is a doll.

When you touch her she will react depending on her level of excitement and her body warms to human body temperature to make her feel even more real.

Our dolls are made with the highest quality materials with fully articulating metal skeletons, and real-feel 100% safe food grade TPE. We use a revolutionary, high-quality TPE material that is more than 2x more flexible and more durable than any TPE doll skin on the market today.

Megan is an affordable, high-quality AI sex doll robot and companion.

Companion Robot

A companion robot is a robot created for the purposes of creating real or apparent companionship for human beings.

Target markets for companion robots include the elderly and single children.

There are several companion robot prototypes and these include Paro, CompanionAble, and EmotiRob, among others.

Paro is a pet-type robot system developed by Japan’s National Institute of Advanced Industrial Science and Technology.

This robot is classified as an FP 7 EU project and is built to “Cooperate with Ambient Assistive Living environment”.

EmotiRob is a robot being developed by a French team to engage fragile children emotionally.

It has cognitive capabilities, which are further extended so that the robot can have a natural linguistic interaction with its owner through the DRAGON speech-recognition software developed by a company called NUANCE. Such interaction is expected to facilitate a child’s cognitive development and develop new learning patterns.

Post Idea #18: Reverse osmosis

Related Articles – Summarized

Reverse Osmosis

This ITG will focus on the chemical and microbiological quality of water produced by reverse osmosis.

Reverse osmosis is a process which uses a membrane under pressure to separate relatively pure water from a less pure solution.

Most RO units with a cellulose acetate membrane are designed to operate between 55 F – 86 F. In practice, the feed water may go through any one or a combination of several of the following pretreatments: sand bed, chlorinator and retention tank, anthracite filter, activated charcoal filter, degasifier, microfilter, neutralizer, and deionizer, depending on the condition of the feed water and the desired quality of the product water.

Since water conditions may vary from time to time, adequate pretreatment must be provided so that the dissolved solids and the bacterial level of the feed water, after prefiltration, can be controlled within the designed limits.

The amount of dissolved solids in water produced by reverse osmosis is approximately a constant percentage of those in the feed water.

A RO water purification system with a deionizer and/or several modules connected in series can produce water containing less than 0.1 ppm TDS. In defining water for use parenterally, Remington’s Pharmaceutical Sciences emphasizes that besides meeting USP pyrogen standards, there are several acceptable levels for total solids which may be used to evaluate or grade the product water for particular applications.

Stagnant water in pipes down stream of the membrane is the major source of bacteria and endotoxin in the product water; and 4.

Definition, Principle, Process, Experiment, Advantages, Disadvantages With FAQs On Reverse Osmosis.

Reverse osmosis is a membrane treatment process primarily used to separate dissolved solutes from water.

Reverse osmosis involves the application of pressure on one side of the solution where a semipermeable membrane is placed in between the solutions.

In essence, reverse osmosis takes place when the solvent passes through the membrane against the concentration gradient.

Such inverse solvent movement through the semipermeable membrane is called reverse osmosis.

In water purification, the reverse osmosis process is very important.

Many water purifiers used today use reverse osmosis in the purification process as one of the steps.

The reverse osmosis process is explained below with the help of an experiment.

Reverse Osmosis

Reverse osmosis is a water purification process that uses a partially permeable membrane to separate ions, unwanted molecules and larger particles from drinking water.

Reverse osmosis is most commonly known for its use in drinking water purification from seawater, removing the salt and other effluent materials from the water molecules.

Portable reverse osmosis water processors can be used by people who live in rural areas without clean water, far away from the city’s water pipes.

Some travelers on long boating, fishing, or island camping trips, or in countries where the local water supply is polluted or substandard, use reverse osmosis water processors coupled with one or more ultraviolet sterilizers.

In the production of bottled mineral water, the water passes through a reverse osmosis water processor to remove pollutants and microorganisms.

Rain water collected from storm drains is purified with reverse osmosis water processors and used for landscape irrigation and industrial cooling in Los Angeles and other cities, as a solution to the problem of water shortages.

Brackish water reverse osmosis refers to desalination of water with a lower salt content than sea water, usually from river estuaries or saline wells.

ScienceDirect Topics

RO membranes are sized on their water volume production rate and the desired hourly or daily rate of pure water to be used and is the most efficient and economical method for removal of contaminants from tap water.

CA is still being successfully used, especially in water treatment with relatively high chlorine tolerance and stability in applications where the feed water has a high fouling potential, such as in municipal effluents and surface water supplies.

Forward OsmosisInstead of high pump pressure, osmotic pressure also can be used to draw water through a membrane to create highly purified drinking water from low-quality source water, including brackish water.

Their economical analysis showed as the treatment cost of produced water is reduced by 30-60%, passing from $0.15 bbl−1 to $0.05-$0.10 bbl−1 when the treated water is sold as drinking water.

To convert oilfield brine to irrigation-quality water, proposed adsorption on modified clay material as pretreatment to MF and RO. They showed that modified clay could remove oil better than activated carbon and RO could remove more than 95% of TDS. Another process for treating oilfield-produced water containing dissolved minerals and hydrocarbons utilizes a warm lime softening system, wherein sludge from the warm lime softening system is recycled to improve lime utilization and enhance silica and boron removal without an external source of magnesium; an MF system and/or an air stripper system may be used with an RO system to produce water that meets guidelines for surface discharge.

The optimal treatment of highly saline wastewater involves a biological treatment of wastewater with acclimated microorganisms in a saline environment prior to membrane systems, especially with RO.The goal of produced water treatment is to remove dissolved components and use the desalted water for beneficial uses, thus effectively reducing environmental impact and water shortage.

Reported the results of a pilot plant where produced water was treated in surfactant-modified zeolite adsorbent units to remove volatile organic compounds and semivolatile organic compounds, an MBR with submerged membranes for removal of the organic acid component of TOC and finally sent to RO. Removal efficiency of SMZ was 40% of the influent TOC; BTEX concentrations were reduced to approximately 2 mg l−1 after the MBR. An economic evaluation showed as-produced water treatment by the SMZ/MBR/RO system would cost $0.13-$0.20 bbl− at up to 40 gal min−1, while estimated disposal costs for produced water are $1.75-$4.91 bbl−, with even higher rates in some regions.

The 7 Best Reverse Osmosis Systems Of 2022

A reverse osmosis system is a specialized form of water filtration that reduces your reliance on plastic bottles by providing clean, potable water right from your tap.

We researched reverse osmosis systems from the top brands, taking into account size, speed, water waste production, and ease of installation, as well as the flavor of the water they produce.

Our top choice is the APEC Water Systems Essence Drinking Water Filter System since it offers five stages of filtration and filters are long-lasting, easy to change, and widely available.

If you’re looking to spend less, consider the PureDrop Five-Stage Reverse Osmosis Water Filtration System.

Water Waste Unlike traditional water filters, not all of the water that is pumped through a reverse osmosis filter comes out the other side as drinkable water.

Container Size Reverse osmosis filtering takes time, so most filters of this type have tanks that store water rather than filtering it on demand.

Filter Speed While there are reverse osmosis filters that can filter water as you need it, most of them take some time to refill.

Post Idea #19: Executive Director

Related Articles – Summarized

Executive Director Definition

An executive director is the senior operating officer or manager of an organization or corporation, usually at a nonprofit.

The executive director is responsible for strategic planning, working with the board of directors, and operating within a budget.

Executive directors report directly to the board and are responsible for carrying out the board’s decisions.

Although an executive director is also involved in the day-to-day management of the organization, these duties may be shared with a chief operating officer.

Executive directors of nonprofit organizations are usually involved with fundraising efforts, as well as the promotion of the organization in order to raise public awareness and boost membership.

Most executive directors are paid; however, for very small NPOs, the position may be on a volunteer basis only.

As a result, executive directors of nonprofits have salaries that are, on average, far less than corporate CEOs.

An executive director is responsible for all of the operations and activities in a company.

A few of the main duties of an executive director are implementing company wide policies, allocating company resources, giving constructive feedback to management, and developing a market strategy.

Some of the jobs titles that an executive director could grow into are chief executive officer and president.

An executive director should have ten years of experience in their respective field as well as an MBA. One of the most important skills that an executive director will have is the ability to initiate change.

Another skill is leadership as the executive director will have many different employees looking to them for guidance.

What responsibilities are common for Executive Director jobs?

What are the typical qualifications for Executive Director jobs?

Executive Director Responsibilities: A Complete Guide

Generally, an executive director is a leader within a company or non-profit organization who oversees and takes responsibilities for tasks relevant to their profession.

For this reason, locating fitting executive talent requires a thorough search and hiring process, which starts with the creation of a comprehensive executive director job description.

To help you create a complete job description, we’ve compiled a list of primary executive director responsibilities and other insights to include when creating an executive director job description.

While there are numerous executive director responsibilities that you can include in a job description, not all of them may be relevant.

After detailing executive director responsibilities and examining a candidate’s qualifications, your next step will be to determine their caliber through an interview.

As executive directors work in numerous industries and can possess a range of skills, there is no true standard salary of the executive director role.

Receive personalized support for your executive search process and find well-performing talent with Recruiterie! Our assistance starts from writing a comprehensive executive director job description to the actual hiring of your successful candidate.

Executive Director

An executive director is a member of a board of directors for an organisation, but the meaning of the term varies between countries.

In the US, an executive director is a chief executive officer or managing director of an organization, company, or corporation.

The title is widely used in North American not-for-profit organizations, though many United States nonprofits have adopted the title president or CEO. Confusion can arise because the words executive and director occur both in this title and in titles of various members of some organizations’ boards of directors.

The executive director is also responsible for the day-to-day operation of the organization, which includes managing committees and staff as well as developing business plans in collaboration with the board.

In essence, the board grants the executive director the authority to run the organization.

The executive director is accountable to the board of directors and reports to the board on a regular basis as defined by the organization’s bylaws.

The executive director is a leadership role for an organization and often fulfills a motivational role in addition to office-based work.

Director Vs Executive Director

Whereas an Executive Director refers to the person in a company, who is considered the Board of Directors head and appointed as a full-time employee of the company which earns a salary from the company over and above director remuneration like an employee.

Here, we provide you with the top 4 differences between Director and Executive Director.

The key differences between Director and Executive Director are as follows: -.

Executive Directors are of various types depending on the number of functions present within an organization like Marketing Directors, Finance Directors, Director for information technology, and Managing Directors.

Let us now look at the head-to-head differences between Director and Executive Director: -.

This article has been a guide to the Director and Executive Director.

Here, we discuss the top differences between Director and Executive Director and infographics and comparison tables.

Executive Director Job Description

We are seeking a self-driven and highly competent executive director to lead and influence our organization towards favorable growth, and to design and direct strategies that support and enhance our organizational operations.

Duties for the executive director will include managing company assets, optimizing financial operations, providing leadership to all staff, establishing business goals, ensuring tax compliance, advising the board of directors on organizational activities, overseeing and streamlining daily operations, improving staff performance, and executing special business projects.

Your exceptional stewardship and strategic planning skills as an executive director will aid our organization in promoting our mission and objectives, maintaining positive relationships with internal and external stakeholders, achieving organizational goals, and maintaining sound financial practices.

The ideal candidate must possess a strong entrepreneurial drive, outstanding communication skills, strong leadership qualities, and good planning and organizational skills.

The exceptional executive director should streamline our organizational operations, effectively and efficiently direct operational budgets, improve revenue, direct our business strategy, and enhance relations with the media, internal stakeholders, staff, and surrounding communities.

Executive Director Responsibilities:Developing and directing organizational strategy.

Executive Director Requirements:Masters in business administration or equivalent.

Post Idea #20: NASDAQ:YNDX

Related Articles – Summarized

Yandex Stock Forecast, Price & News

Yandex NV engages in the provision of search engines and online services.

It operates through the following segments: Search and Portal; Yandex Market; Taxi; Media Services; Classifieds; and Other Bets and Experiments.

The Search and Portal segment includes all the services offered in Russia, Belarus, and Kazakhstan.

The Taxi segment covers the ride-sharing business, which consists of Yandex Taxi as well as Uber in Russia and other countries.

The Yandex Market segment encompasses price comparison service, e-commerce marketplace and several small experiments.

The Classifieds Segment deals with online advertising and listing fees.

The Other Bets and Experiments segment consists of smaller business units and experiments.

Yandex Stock Price, News & Info

If Russia can just refrain from invading Ukraine, Yandex stock might go even higher.

YNDX earnings call for the period ending June 30, 2020.

YNDX earnings call for the period ending September 30, 2019.

YNDX earnings call for the period ending June 30, 2019.

YNDX earnings call for the period ending March 31, 2019.

YNDX earnings call for the period ending December 31, 2018.

YNDX earnings call for the period ending September 30, 2018.

Post Idea #21: Annotation

Related Articles – Summarized

Annotation Definition & Meaning

Without the annotations, the diagram would be hard to understand.

Make sure annotation guidelines are clear and there is consistency across the decisions made by different annotators.

Sandeep Konam, Quartz, 2 Mar. 2022 There is no dot-dot-dot icon to demonstrate that a non-iPhone user is typing, for example, and an iMessage heart or thumbs-up annotation has long conveyed to Android users as text instead of images.

Jacob Carpenter, Fortune, 10 Jan. 2022 There is no dot-dot-dot icon to demonstrate that a non-iPhone user is typing, for example, and an iMessage heart or thumbs-up annotation has long conveyed to Android users as text instead of images.

Jacob Carpenter, Fortune, 10 Jan. 2022 As opposed to supervised deep learning approaches, Helm espouses unsupervised learning or deep teaching, wherein large amounts of data can used to train computers without image annotation and human intervention.

Sabbir Rangwala, Forbes, 31 Jan. 2022 There is no dot-dot-dot icon to demonstrate that a non-iPhone user is typing, for example, and an iMessage heart or thumbs-up annotation has long conveyed to Android users as text instead of images.

Tim Higgins, WSJ, 8 Jan. 2022 These example sentences are selected automatically from various online news sources to reflect current usage of the word ‘annotation.

Definition Of Annotation By Medical Dictionary

Annotation Bioinformatics A term of art referring to analysis and commentary added to sequence data in databases, which provide contextual information about coding and non-coding sequence within genes, patterning and motifs, similarities, known or predicted protein structure and function, and links to external data.

Informatics A critical or explanatory note, usually included in a bibliographical entry or reference, to provide additional data.

Annotation process used in GENOMICS for analysis of NUCLEOTIDE SEQUENCES to identify the GENES, their regulatory sequences (see OPERON MODEL and their functions.

Annotation also includes characterization of MOBILE GENETIC ELEMENTS and REPETITIVE DNA. See also BIOINFORMATICS. Collins Dictionary of Biology, 3rd ed.

Annotation Legal Definition Of Annotation

A note, summary, or commentary on some section of a book or a statute that is intended to explain or illustrate its meaning.

An annotation serves as a brief summary of the law and the facts of a case and demonstrates how a particular law enacted by Congress or a state legislature is interpreted and applied.

Annotations usually follow the text of the statute they interpret in annotated statutes.

In another sense, annotations were the answers of the prince to questions put to him by private persons respecting some doubtful point of law.

Annotation Examples & Techniques

The reader may want to share his, her, or their thoughts with a reading community of sorts through a book review, a blog, or book club, and annotations allow for easy retrieval of information to discuss.

There are some techniques for annotating to make it an efficient process, though the most important aspect of creating annotations is that they make sense to the reader.

The most important factor is that the technique makes sense to the reader and can be used for the reader’s intended purpose after reading.

Annotation Web Add-Ons: If a person is doing a lot of e-reading on websites, using a browser add-on might be more useful than trying to take hand-written notes, as these add-ons will allow the reader to type onto a webpage or PDF article and save it for later reference.

Keeping in mind that the purpose of annotating is for efficient review of material after reading, it is important to remain consistent with one’s techniques and formats so that this goal is met.

All of the techniques and formats listed above are best suited for annotating while reading rather than after reading.

To review, annotating a text is a common practice for readers who want to come back to their thoughts, ideas, questions, or realizations after reading.

Annotation Examples Simply Explained

Ultimately, annotations help readers to understand the main text and ensure the reader has all the information they need.

Examples of Annotations in an Annotated Bibliography.

Gov/health…This is a comprehensive listing of anxiety-related disorders with descriptions of each disorder and narratives from those who have coped with the symptoms.

There is information about research currently underway to help with these disorders.

Dialectical Behavior Therapy, initially created as a means of treatment for those with bipolar disorder who showed suicidal tendencies, is now a more generalized method of treatment, established as effective for many psychological disorders.

Six different disorders were studied using placebos to study the effects.

The list offers some informative texts that would be helpful to those whose family members, friends, or other loved ones are trying to cope with anxiety-related disorders.

Annotating Texts

Why annotate? Isolate and organize important material.

Some browsers have add-ons or extensions that allow you to annotate web pages or web-based documents.

Can your digital text be imported into a note-taking tool like OneNote, EverNote, or Google Keep? If so, you might be able to annotate texts in those apps.

As you annotate a text, ask yourself: how would I explain this to a friend?

A common concern about annotating texts: It takes time!

Your annotated notes will help speed up exam prep, because you can review critical concepts quickly and efficiently.

One last tip: Try separating the reading and annotating processes! Quickly read through a section of the text first, then go back and annotate.

English Composition I: Rhetorical Methods-Based

The problem is many students spend hours reading and have no idea what they just read. Their eyes are moving across the page, but their mind is somewhere else.

The end result is wasted time, energy, and frustrationand having to read the text again.

Although students are taught how to read at an early age, many are not taught how to actively engage with written text or other media.

Annotating a text or other media is as much about you as it is the text you are annotating.

One of the ways proficient readers read is with a pen in hand.

Review the video, “How to Annotate a Text.” Pay attention to both how to make annotations and what types of thoughts and ideas may be part of your annotations as you actively read a written text.

In addition to annotating written text, at times you will have assignments to annotate media.

Post Idea #22: Aerial work platform

Related Articles – Summarized

Aerial Work Platforms

Aerial Work Platforms, Inc. is proudly locally owned and operated in Wisconsin.

We have provided the construction industry with the rental, service, and sale of aerial work platforms since 1979.

We continually earn our customer’s repeat business due to the superior customer service, satisfaction, and value we provide.

We are the first authorized Genie dealer in Wisconsin.

Our fleet consists of scissor lifts, boom lifts, telehandlers, personnel & material lifts, forklifts and more from trusted names such as Genie, Skyjack, JLG, Hybrid, and Nifty-Lift.

We look forward to the opportunity to earn your business.

What Is An Aerial Work Platform?

People would not be able to enjoy the modern urban infrastructure – all those skyscrapers, bridges, industrial facilities and even suspended banners – in the absence of aerial work platforms.

Depending on the project requirements, an organization can be recommended a certain model of an aerial work platform.

The place of aerial work platforms in the global industry.

Speaking of AWP as the driving force of the global industry, we should say that no other equipment is going to replace aerial work platforms in the foreseeable future.

Demand breeds supply, and companies, that offer aerial work platforms for rent, try to strengthen their competitive ability by improving technologies, client support, strategic collaborations, extra services etc.

Aerial work platforms can get to the place of your project without any other means of transportation, they help to elevate people, materials and tools at the required height, to access the areas that cannot be reached otherwise.

S-120 double articulated aerial work platform equipped with a jib is always ready to elevate three operators and instruments at the height of up to 120 feet while maneuvering around various obstacles on site.

Aerial Work Platforms

Genie® AWP™, DPL™ and IWP™ aerial work platforms are easy to use and cost effective, making them the first choice for a wide range of applications.

One person can easily set them up and get to work within minutes, providing the ideal all-around tool for almost any access application.

Their lightweight and compact size makes Genie aerial work platforms convenient to use in schools, churches, warehouses and more.

Genie aerial work platforms also provide solutions for interior work on large construction sites, such as high rises, as well as being perfect for light-duty construction purposes.

Aerial Work Platforms For Rent

See below for the largest aerial equipment rental fleet in the world.

Our aerial equipment includes cherry picker lifts, personnel lifts, scissor lifts for indoor or outdoor applications, boom lifts for straight reach jobs, and articulating boom lifts for spots that aren’t easily accessible – all sourced from top-tier mobile elevated work platform manufacturers.

Our gas and diesel aerial work platforms are built to navigate difficult outdoor worksite terrain, while our electric and propane aerial lifts easily maneuver through indoor environments with clean, fume-free operation.

Whether you’re a service professional doing indoor repairs and maintenance at 30 feet or a contractor completing a new construction fabrication at 150 feet, we have the aerial lift equipment for rent to fit your project needs.

Platform height is the total height the base of the equipment cage reaches at its highest point, fully extended.

Add the maximum height an operator can reach to the platform height, and you have the working height.

United Rentals rents equipment from top-tier manufacturers in the industry, such as Genie boom lifts, Skyjack vertical lifts and JLG boom lifts.

Aerial Work Platforms This Aerial Work Platform Safety Program covers any equipment that is used primarily for mechanically elevating personnel, along with their tools and equipment, on a platform.

Definitions Aerial device or aerial work platform means an entire device that is designed and manufactured to raise personnel to an elevated work position on a platform supported by scissors, masts, or booms.

Telescopic derricks with personnel platform attachments shall be considered to be extensible boom platforms when used with a personnel platform.

All aerial work platforms manufactured before July 1, 2006, shall meet the design and construction requirements of ANSI A92.2-1969, American National Standard for VehicleMounted Elevating and Rotating Work Platforms.

Pdf Workplace Survey Before using an aerial work platform, the operator shall survey the area for hazards such as: Untamped earth fills Ditches Drop-offs and floor obstructions Debris Overhead obstructions and electrical conductors Weather conditions Unauthorized persons in the area Uneven ground that exceeds the manufacturer’s requirements for slope All potentially unsafe conditions identified in either the visual inspection, equipment check, or area inspection must be corrected prior to using the aerial work platform.

Moving the Aerial Work Platform Make sure the boom is properly cradled and the outriggers are in the stowed position before moving the aerial work platform.

The aerial work platform may be moved with the boom elevated and personnel on the platform only if the equipment was specifically designed for such use and the manufacturer allows for this type of operation.

Aerial Work Platforms

With impressive working heights and outreaches, PALFINGER Aerial Work Platforms are designed to enhance your performance on any high altitude job.

Easy to maneuver, PALFINGER Platforms can be driven to any jobsite and are stabilized and fully ready to work within minutes.

PALFINGER aerial work platforms make an impression with their safe and reliable height access technology.

Aerial Work Platforms, Sales, Service, Parts And Repairs.

The largest Aerial Work Platform Dealer in the US.Aerial work platforms, aerial lift, boom lift, and scissor lift wholesaler.

Boom manlifts, scissor manlifts, man lifts, bucket truck manlifts by: Bil Jax manlifts.

Bil-Jax has grown to become North America’s largest manufacturer ofinterior and exterior scaffolds, aerial lifts, event seating and staging, elevating trailers,and other construction related products.

The Bil Jax line of over 6,000 different finished parts is still the most comprehensive product offering in the industry.

All models offer one person operation, ground level deck lowering, towing ease, smooth ride fully loaded, quality painted finish, diamond tread-plated deck, and heavy duty construction for years of durable, reliable service.

Post Idea #23: Takeuchi Manufacturing

Related Articles – Summarized

Compact Construction Equipment

Takeuchi compact track loaders are designed to be powerful and efficient and engineered to provide superior value, durability, power, and maneuverability.

All Takeuchi excavators are rugged, dependable and productive.

They provide exceptional value, demonstrate outstanding performance, and are measured by their longevity in the field.

Takeuchi wheel loaders provide incredible reach and dump height for outstanding material handling, and the spacious operator’s station is elevated giving the operator greater visibility.

Takeuchi provides a wide range of attachments for our excavators, track loaders and wheel loaders.

All of our attachments are high performance and help you tackle any job.

Construction Equipment

Takeuchi is a global manufacturer, headquartered in Japan.

It manufactures and distributes compact track loaders, compact excavators, compact wheel loaders, and attachments in the United States.

Takeuchi manufacturing began in 1963 and has been a pioneer in the compact equipment industry.

Takeuchi developed the world’s first compact excavator in 1971, and then in the mid-1980s introduced the first compact track loader.

Takeuchi has an extensive dealer and service network throughout North America that is supported by a state-of-the-art training, parts and distribution facility near Atlanta, Georgia.

Takeuchi Manufacturing

Takeuchi Mfg. Co., Ltd. is Japanese heavy-machinery company that produces mini excavators, hydraulic excavators, and crawler loaders.

In 1971 Takeuchi introduced the first compact excavator.

The company has wholly owned subsidiary facilities in the United States, United Kingdom, France and China.

Takeuchi was founded in 1963 as an environmental equipment manufacturer.

They were the first company to introduce the compact excavator to North America, setting the stage for one of the highest-growth product segments ever introduced in the compact equipment market.

The compact excavator market has become a main product for rental and construction/utility companies.

Post Idea #24: Kobe Steel

Related Articles – Summarized

Kobe Steel

Kobe Steel, Ltd., operating worldwide under the brand Kobelco, is a major Japanese steel manufacturer headquartered in Chūō-ku, Kobe.

Its main production facilities are Kakogawa Steel Works and Kobe Steel Works.

Kobe Steel is the owner of the rugby team Kobelco Steelers.

In 2016, Kobe Steel lost ¥23 billion due to cheap aluminium and steel imports.

In October 2017, Kobe Steel admitted to falsifying data on the strength and durability of its aluminum, copper and steel products.

Following further news in October 2017 that car makers Toyota, Nissan, and General Motors, and train manufacturer Hitachi, were among 200 companies affected by the Kobe Steel’s mislabelling, which had potential safety implications for their vehicles, the CEO of Kobe Steel conceded that his company now had “Zero credibility”.

Iron & Steel: ordinary wire rod, specialty steel wire rod, specialty steel wire, ordinary steel bar, specialty steel bar, heavy plate, medium plate and sheet, titanium and titanium alloys, foundry pig iron and pig iron for steelmaking, stainless steel tube, specialty steel products, wholesale electric power supply.

Trawling through Kobe’s report, it’s clear there is plenty wrong at the heart of Japan’s third-biggest steelmaker.

Essentially Kobe employees put making money above telling the truth to their customers.

At least two of Kobe’s directors knew what was going on – so it wasn’t as if these issues were undetected.

Analysts have suggested one reason for the cover-up was that Kobe, like many other Japanese steelmakers, has been under pressure as Chinese steel firms flood global markets with excess supply.

Kobe staff felt they could deliver products that fell short of customer specifications to their clients, as long they had no safety issues.

Kobe is now taking steps to fix some of these problems.

Fixing corporate governance issues, introducing a more transparent and accountable board and basically making sure staff don’t tell lies will be key priorities for Kobe as it tries to clean up this mess.

Shareholders Board Members Managers And Company Profile

Kobe Steel, Ltd. specializes in manufacturing and marketing of steel and metallurgical products.

The group is also developing production of construction and industrial machines activity.

Sale of steel and metallurgical products: special steel wires, stainless tubes, rolled steel products, steel strips, plates, titanium alloys, building materials, etc.

Manufacturing of construction machines: cranes, hydraulic excavators, mini excavators and wheeled loaders;.

Sale of copper and aluminum products: copper strips for semiconductors, copper tubes for air conditioners, aluminum foils, aluminum alloys products, etc.

Manufacturing of industrial machines: compressors, high pressure machines, heat pumps, nuclear plants equipments, etc.

Other: primarily sale of electronic equipments and real estate development.

Kobe Steel Ethical Issues Case Study Free Essay Sample On Samploon.Com

Kobe Steel is a well-known steel maker, and is one of the largest companies of its kind in the world “With more than 200 subsidiaries and 62 affiliated companies in Europe, Asia, and North America.” However, for the last 10 years they have been conducting unethical practices such as falsifying data and selling substandard metal to unknowing consumers.

Various ethical theories including Utilitarian, Aristotle’s theory of virtue, and Kant’s Theory, all support the idea that Kobe Steel was wrong in their business practices.

Ethical issues are actions that a company or person does that is immoral or shows no regard in how they treat others.

Another ethical issue for them is that if the cars or airplanes do not hold up well it could hurt the car or airplane companies that they sold the metal to.

In the case with Kobe Steel, Utilitarian theory would not condone their actions because they were solely thinking of themselves and no one else.

The employees at Kobe Steel are the opposite of a virtuous person.

In conclusion, this case study shows how many companies are unethical in their practices and just because it is corporate culture, does not make it right.

Kobe Steel Group

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Kobe Steel Admits Data Fraud Went On Nearly Five Decades, CEO To Quit

5 Min Read.TOKYO – Kobe Steel Ltd admitted on Tuesday its data fraud has been going on nearly five decades and also revealed new cases of cheating, highlighting the challenges facing the 112-year-old company mired in compliance failures and malfeasance.

Japan’s third-biggest steelmaker said its CEO will step down to take responsibility for the widespread data fraud scandal that came to light last year, although doubts remain over its corporate culture and the possibility of future fines.

Kobe Steel, which supplies steel parts to manufacturers of cars, planes and trains around the world, admitted last year to supplying products with falsified specifications to about 500 customers, throwing global supply chains into turmoil.

Kobe Steel said the data cheating started at least as early as the 1970s, based on testimony from multiple sources interviewed by the external investigation team.

Kobe Steel has had a series of scandals in the last dozen years, including taking part in bid-rigging for a bridge project in 2005, failing to report income to tax authorities in 2008, 2011 and 2013, and falsifying emissions data in 2006.

The data fraud scandal so far appears to have left Kobe Steel’s finances unscathed.

“There is a pending risk for Kobe Steel as customers at home or abroad may cancel their contracts and take legal actions, and the U.S. Justice Department may seek a penalty,” said Makiko Yoshimura, director at S&P Global Rating Japan.

Post Idea #25: Key management

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Apartments, Houses & Senior Rentals

Key Management Company, based in Wichita, Kansas with satellite offices in Kansas, Missouri, and Oklahoma, offers premier property management services for residential and commercial property owners nationwide.

We offer full-service management of houses, apartment communities, senior housing, and commercial spaces.

Leasing properties through intelligent targeted marketing while taking care of all maintenance and make-ready requirements, including the provision of onsite management and maintenance professionals for apartment and senior living communities, providing a hassle-free service for residents and property owners.

Our dedicated marketing team constantly research the market to put your property front and center where renters are looking for homes using high-quality professional photography.

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How Does Key Management Work?

The private keys of the code-signing certificate can be stored in an HSM to eliminate the risks associated with stolen, corrupted, or misused keys.

Client-side hashing ensures build performance and avoids unnecessary movement of files to provide a greater level of security.

The command line signing tool provides a faster method to sign requests in bulk.

Robust access control systems can be integrated with LDAP and customizable workflows to mitigate risks associated with granting wrong access to unauthorized users, allowing them to sign code with malicious certificates.

Support for customized workflows of an “M of N” quorum with multi-tier support of approvers.

Support for InfosSec policies to improve adoption of the solution and enable different business teams to have their own workflow for Code Signing.

Validation of code against UpToDate antivirus definitions for virus and malware before digitally signing it will mitigate risks associated with signing malicious code.

Key Management

Part 1 provides general guidance and best practices for the management of cryptographic keying material, including definitions of the security services that may be provided when using cryptography and the algorithms and key types that may be employed, specifications of the protection that each type of key and other cryptographic information requires and methods for providing this protection, discussions about the functions involved in key management, and discussions about a variety of key-management issues to be addressed when using cryptography.

Part 2 provides guidance on policy and security planning requirements for U.S. Government agencies.

Part 3 provides guidance when using the cryptographic features of current systems.

Part 1 provides general guidance and best practices for the management of cryptographic keying material.

Part 2 provides guidance on policy and security planning requirements for U.S. government agencies.

Finally, Part 3 provides guidance when using the cryptographic features of current systems.

Key Management Transitions SP 800-131A Revision 2, Transitioning the Use of Cryptographic Algorithms and Key Lengths Provides guidance for transitions to the use of stronger cryptographic keys and more robust algorithms by federal agencies when protecting sensitive, but unclassified information.

Key Management

Public key infrastructure, the implementation of public key cryptography, requires an organization to establish an infrastructure to create and manage public and private key pairs along with digital certificates.

Since the Diffie-Hellman key exchange protocol was published in 1975, it has become possible to exchange a key over an insecure communications channel, which has substantially reduced the risk of key disclosure during distribution.

The German Army Enigma symmetric encryption key was a mixed type early in its use; the key was a combination of secretly distributed key schedules and a user chosen session key component for each message.

In more modern systems, such as OpenPGP compatible systems, a session key for a symmetric key algorithm is distributed encrypted by an asymmetric key algorithm.

A key management system, also known as a cryptographic key management system or enterprise key management system, is an integrated approach for generating, distributing and managing cryptographic keys for devices and applications.

The security policy of a key management system provides the rules that are to be used to protect keys and metadata that the key management system supports.

IETF.org released RFC 4046, entitled Multicast Security Group Key Management Architecture, which discusses the challenges of group key management.

Activate Using Key Management Service

Installing a KMS host key on a computer running Windows 10 allows you to activate other computers running Windows 10 against this KMS host and earlier versions of the client operating system, such as Windows 8.1 or Windows 7.

Clients locate the KMS server by using resource records in DNS, so some configuration of DNS may be required.

To enable KMS functionality, a KMS key is installed on a KMS host; then, the host is activated over the Internet or by phone using Microsoft activation services.

Key Management Service in earlier versions of Windows.

If you have already established a KMS infrastructure in your organization for an earlier version of Windows, you may want to continue using that infrastructure to activate computers running Windows 10 or Windows Server 2012 R2. Your existing KMS host must be running Windows 7 or later.

Request a new KMS host key from the Volume Licensing Service Center.

For detailed instructions, see Update that enables Windows 8.1 and Windows 8 KMS hosts to activate a later version of Windows and Update that enables Windows 7 and Windows Server 2008 R2 KMS hosts to activate Windows 10.

Glendale Homes For Rent

Welcome to Key Management Co., Inc.We are an established property management company in the Phoenix, AZ area, providing homes for rent and property management services to Phoenix, Peoria, Glendale, Avondale, Tolleson, Surprise and Litchfield Park since 1981.

We care about you as an owner and we care about your Glendale rental property.

We act in the best interest of the owner and are dependable.

We are professional phoenix property managers and we want to protect your investment.

We do not market properties for sale, therefore all our experience and efforts are directed to the property management process.

Downtown Milwaukee Area Apartments

Featuring: Affordable downtown living with expansive open floor plans!

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Our apartment communities are found in some of Milwaukee’s most historic and charming buildings that have retained their old-world charm and vintage details while adding the comfort and convenience of modern day amenities.

Post Idea #26: Anxiety disorder

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Symptoms And Causes

Examples of anxiety disorders include generalized anxiety disorder, social anxiety disorder, specific phobias and separation anxiety disorder.

Anxiety disorder due to a medical condition includes symptoms of intense anxiety or panic that are directly caused by a physical health problem.

Generalized anxiety disorder includes persistent and excessive anxiety and worry about activities or events – even ordinary, routine issues.

Separation anxiety disorder is a childhood disorder characterized by anxiety that’s excessive for the child’s developmental level and related to separation from parents or others who have parental roles.

Substance-induced anxiety disorder is characterized by symptoms of intense anxiety or panic that are a direct result of misusing drugs, taking medications, being exposed to a toxic substance or withdrawal from drugs.

The causes of anxiety disorders aren’t fully understood.

In some cases, anxiety signs and symptoms are the first indicators of a medical illness.

NIMH » Anxiety Disorders

For a person with an anxiety disorder, the anxiety does not go away and can get worse over time.

There are several types of anxiety disorders, including generalized anxiety disorder, panic disorder, and various phobia-related disorders.

People with generalized anxiety disorder display excessive anxiety or worry, most days for at least 6 months, about a number of things such as personal health, work, social interactions, and everyday routine life circumstances.

Social anxiety disorder: People with social anxiety disorder have a general intense fear of, or anxiety toward, social or performance situations.

Separation anxiety disorder: Separation anxiety is often thought of as something that only children deal with; however, adults can also be diagnosed with separation anxiety disorder.

Some benefits of benzodiazepines are that they are effective in relieving anxiety and take effect more quickly than antidepressant medications often prescribed for anxiety.

Stress management techniques and meditation can help people with anxiety disorders calm themselves and may enhance the effects of therapy.

What Are The Five Major Types Of Anxiety Disorders?

Generalized Anxiety DisorderGeneralized Anxiety Disorder, GAD, is an anxiety disorder characterized by chronic anxiety, exaggerated worry and tension, even when there is little or nothing to provoke it.

Obsessive-Compulsive DisorderObsessive-Compulsive Disorder, OCD, is an anxiety disorder and is characterized by recurrent, unwanted thoughts and/or repetitive behaviors.

Performing these so-called “Rituals,” however, provides only temporary relief, and not performing them markedly increases anxiety.

Panic DisorderPanic disorder is an anxiety disorder and is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Post-Traumatic Stress DisorderPost-Traumatic Stress Disorder, PTSD, is an anxiety disorder that can develop after exposure to a terrifying event or ordeal in which grave physical harm occurred or was threatened.

Traumatic events that may trigger PTSD include violent personal assaults, natural or human-caused disasters, accidents, or military combat.

Or Social Anxiety Disorder, is an anxiety disorder characterized by overwhelming anxiety and excessive self-consciousness in everyday social situations.

Anxiety Disorder

The umbrella term anxiety disorder refers to a number of specific disorders that include fears or anxiety symptoms.

There are several types of anxiety disorders, including generalized anxiety disorder, specific phobia, social anxiety disorder, separation anxiety disorder, agoraphobia, panic disorder, and selective mutism.

If a person is diagnosed with an anxiety disorder, a medical professional must have evaluated the person to ensure the anxiety cannot be attributed to another medical illness or mental disorder.

Generalized anxiety disorder is a common disorder, characterized by long-lasting anxiety which is not focused on any one object or situation.

Generalized anxiety disorder is the most common anxiety disorder to affect older adults.

Like adults, children can experience anxiety disorders; between 10 and 20 percent of all children will develop a full-fledged anxiety disorder prior to the age of 18, making anxiety the most common mental health issue in young people.

Anxiety in children is sometimes misdiagnosed as attention deficit hyperactivity disorder or, due to the tendency of children to interpret their emotions physically, anxiety disorders may initially be confused with physical ailments.

What Are Anxiety Disorders?

Anxiety disorders differ from normal feelings of nervousness or anxiousness and involve excessive fear or anxiety.

Anxiety disorders are the most common of mental disorders and affect nearly 30% of adults at some point in their lives.

Generalized anxiety disorder: 2%. separation anxiety disorder: 0.9% – 1.9%. Women are more likely than men to experience anxiety disorders.

There are several types of anxiety disorders, including generalized anxiety disorder, panic disorder, specific phobias, agoraphobia, social anxiety disorder and separation anxiety disorder.

Anxiety disorders can run in families, suggesting that a combination of genes and environmental stresses can produce the disorders.

Many people with anxiety disorders don’t seek help.

There are a number of things people do to help cope with symptoms of anxiety disorders and make treatment more effective.

Anxiety Disorders: Types, Causes, Symptoms & Treatments

There are several effective treatments for anxiety disorders.

These attacks often feature stronger, more intense feelings than other types of anxiety disorders.

Researchers don’t know exactly what causes anxiety disorders.

Beta-blockers, usually used for high blood pressure, can help reduce some of the physical symptoms of anxiety disorders.

There are several treatments for anxiety disorders.

If you notice symptoms of an anxiety disorder, talk to your healthcare provider.

Symptoms of an anxiety disorder can resemble symptoms of a heart attack or another health emergency.

Anxiety: What It Is, What To Do

While anxiety symptoms vary widely, odds are good that at some point you’ve experienced occasional physical and emotional distress signals such as panicky breathing, your heart pounding in your chest, trouble sleeping, feelings of dread, or even loops of worry.

“A certain amount of anxiety can even be helpful. The problem is that sometimes the systems underlying our anxiety responses get dysregulated, so that we overreact or react to the wrong situations.”

Generalized anxiety disorder: A pattern of excessive worry about a variety of issues on most days for at least six months, often accompanied by physical symptoms, such as muscle tension, a hammering heart, or dizziness.

Social anxiety disorder: Feeling significant anxiety in social situations or when called on to perform in front of others, such as in public speaking.

Intrusive thoughts, dread of panic attacks, intense self-consciousness and fear of rejection, and other hallmarks of anxiety disorders compel people to avoid anxiety-provoking situations.

Exposure therapy helps people tolerate and calm anxiety by gradually exposing a person to feared situations or objects under guidance from a therapist.

Relieving anxiety with medicine while using CBT or exposure therapy to strengthen coping skills and help retrain the brain can do much to make anxiety manageable.

Post Idea #27: Peripheral artery disease

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Peripheral Arterial Disease

PAD can happen in any blood vessel, but it is more common in the legs than the arms.

If you have PAD, you are at risk for developing coronary artery disease and cerebrovascular disease, which could lead to a heart attack or stroke.

The classic symptom of PAD is pain in the legs with physical activity, such as walking, that gets better after rest.

Physical signs in the leg that may indicate PAD include muscle atrophy; hair loss; smooth, shiny skin; skin that is cool to the touch, especially if accompanied by pain while walking; decreased or absent pulses in the feet; sores or ulcers in the legs or feet that don’t heal; and cold or numb toes.2,3.

Smoking increases the risk of PAD and makes PAD symptoms worse.

If you have symptoms of PAD, your doctor may do an ankle brachial index, which is a noninvasive test that measures the blood pressure in the ankles and compares it with the blood pressure in the arms at rest and after exercise.

How is PAD treated? Your doctor may recommend that you take aspirin or other similar antiplatelet medicines to prevent serious complications from PAD and associated atherosclerosis.

Peripheral Artery Disease

Peripheral artery disease is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs.

Peripheral artery disease is also likely to be a sign of a buildup of fatty deposits in your arteries.

While many people with peripheral artery disease have mild or no symptoms, some people have leg pain when walking.

Under age 50 and have diabetes and other peripheral artery disease risk factors, such as obesity or high blood pressure.

Less commonly, the cause of peripheral artery disease may be blood vessel inflammation, injury to your limbs, unusual anatomy of your ligaments or muscles, or radiation exposure.

A family history of peripheral artery disease, heart disease or stroke.

People who smoke or have diabetes have the greatest risk of developing peripheral artery disease due to reduced blood flow.

Peripheral Artery Disease

In the United States, more than 8 million people age 40 and older have peripheral artery disease, or PAD. PAD is caused by atherosclerosis, or plaque buildup, that reduces the flow of blood in peripheral arteries-the blood vessels that carry blood away from the heart to other parts of the body.

This health topic focuses on the most common type of PAD, called “Lower extremityPAD,” which reduces blood flow to the legs and feet.

You may have lower extremity PAD if you have muscle pain or weakness that begins with physical activity, such as walking, and stops within minutes after resting.

About 1 in 4 people who have PAD experience these symptoms.

If you smoke or have high blood pressure or other risk factors for PAD, even without symptoms, ask your doctor about getting tested.

It is important to be aware that if you have lower extremity PAD, you may also have plaque buildup in other arteries leading to and from your heart and brain, putting you at higher risk of stroke or heart attack.

Early diagnosis and management of PAD can help treat your symptoms and reduce your risk for serious complications.

Peripheral Arterial Disease

This activity describes the evaluation and management of peripheral arterial disease and reviews the role of the interprofessional team in improving care for patients with this condition.

Patients with peripheral arterial disease have decreased lower extremity arterial perfusion which is commonly referred to as “Poor circulation.” In most cases of PAD, atherosclerotic plaques narrow the arterial flow lumen which restricts blood flow to the distal extremity.

Symptoms during walking occur in the muscle group one level distal to the artery narrowed or blocked by PAD. Patients with aortoiliac artery occlusive disease have symptoms in the thigh and buttock muscles while patients with femoropopliteal PAD have symptoms in their calf muscles.

All patients with PAD, regardless of the presence or absence of symptoms, have an increased risk of stroke, myocardial infarction, and thrombosis compared to patients without arterial disease.

Treatment options to improve walking ability vary depending on the patient’s symptoms and disease severity.

The technical success and durability of endovascular therapy decrease in patients with long-segment total occlusions and infrapopliteal arterial occlusive disease.

19.Chan AS, Montbriand J, Eisenberg N, Roche-Nagle G. Outcomes of minor amputations in patients with peripheral vascular disease over a 10-year period at a tertiary care institution.

What Is Peripheral Artery Disease?

Peripheral artery disease, sometimes called peripheral arterial disease or PAD, is a condition in which your arteries are narrowed and can’t carry as much blood to the outer parts of your body, like your arms and legs.

The most common cause of PAD is a blockage in the arteries, the vessels that carry blood away from the heart.

If you have leg pain when you walk or any other PAD symptoms, talk to your doctor about it.

Even if you don’t have symptoms, ask your doctor about PAD if you’re 70 or older.

Your doctor will start with a physical exam to look for signs of PAD. They might check blood flow in your legs and feet and listen for a whooshing sound in your leg arteries.

There are some simple things your doctor might recommend to help manage your symptoms and keep your PAD from getting worse.

Manage conditions: Treat or help prevent conditions that raise your PAD risk like high blood pressure, diabetes, and high cholesterol.

Peripheral Artery Disease

Peripheral artery disease is an abnormal narrowing of arteries other than those that supply the heart or brain.

Peripheral artery disease most commonly affects the legs, but other arteries may also be involved – such as those of the arms, neck, or kidneys.

Smoking – tobacco use in any form is the single greatest risk factor of peripheral artery disease internationally.

While there are genetics leading to risk factors for peripheral artery disease, including diabetes and high blood pressure; there have been no specific genes or gene mutations directly associated with the development of peripheral artery disease.

Testing for coronary artery disease or carotid artery disease is of unclear benefit.

According to guidelines, taking aspirin or clopidogrel is recommended to reduce AMI, stroke, and other causes of vascular death in people with symptomatic peripheral artery disease.

Peripheral artery disease affects one in three diabetics over the age of 50.

Post Idea #28: People’s Bank of China

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People’S Bank Of China

Central bank of the People’s Republic of China.

The People’s Bank of China is the central bank of the People’s Republic of China responsible for carrying out monetary policy and regulation of financial institutions in mainland China, as determined by People’s Bank Law and Commercial Bank Law.

The bank was established on December 1, 1948, based on the consolidation of the Huabei Bank, the Beihai Bank and the Xibei Farmer Bank.

Between 1950 and 1978 the PBC was the only bank in the People’s Republic of China and was responsible for both central banking and commercial banking operations.

All other banks within Mainland China such as the Bank of China were either organized as divisions of the PBC or were non-deposit taking agencies.

With the exception of special allocations for rural development, the monolithic PBC dominated all business transactions and credit until 1978, when, as part of the Chinese economic reforms, the State Council split off the commercial banking functions of the PB into four independent but state-owned banks, including the Industrial and Commercial Bank of China, the Bank of China, the Agricultural Bank of China, and the China Construction Bank.

In 1983, the State Council promulgated that the PBC would function as the central bank of China.

People’S Bank Of China

The People’s Bank of China is the central bank of the People’s Republic of China and is located in Beijing.

The Huabei Bank, the Beihai Bank, and the Xibei Farmer Bank were consolidated to form the PBOC after the Chinese Communist Party’s victory and the creation of the People’s Republic of China.

In September 1982, the State Council decided that the PBOC should become the central bank.

Between 1950 and 1978, the PBOC was the only bank in the nation and oversaw both central banking and commercial banking operations.

All other banks within Mainland China, such as the Bank of China, were either divisions of the PBOC or did not accept deposits.

The interest rate set by the bank was historically always divisible by nine instead of by 25 as is the case for the rest of the world.

The central bank began to increase rates by 0.25% on Oct. 19, 2010, and the interest rate is now divisible by 25.

History, Structure And Functions

The People’s Bank of China is the main bank of the People’s Republic of China.

PBOC was formed in 1947 as a result of the merger and nationalization of three major commercial financial institutions: Huabei Bank, Beihai Bank and Sibei Agricultural Bank.

From 1949 to 1978, the PBOC was the only bank in the republic.

During this period, he not only performed the functions of the Central Bank, but also conducted all operations of a commercial bank, including servicing organizations and working with private deposits.

By the decision of the State Council of the People’s Republic of China, since 1983, the People’s Bank of China has exclusively retained the functions of the Central Bank.

The legal position of the Central Bank was finally determined on March 18, 1995 at the III Plenum of the National People’s Congress.

The PBOC structure includes a center for countering money laundering, a banking school, a publishing house of financial literature, a news agency, a settlement center, banknote and coin minting enterprises, a currency trading system, etc.

People’S Bank Of China

The People’s Bank of China is the Chinese central bank, which was founded on December 1st, 1948.

The People’s Bank of China is responsible for designing and implementing the monetary policy of China.

The bank is also responsible for issuing the Chinese official currency the Renminbi and its circulation.

Another major responsibility for of People’s Bank of China is the regulation of the Chinese financial markets, which includes bank-to-bank lending market, bank-to-bank bond market, FOREX and gold markets.

The bank is also accountable for the smooth operation of the payment and settlement markets in China.

The People’s Bank of China manages the State treasury as well.

The People’s Bank of China uses several monetary instruments in its monetary policy implementation, including influencing short-term interest rates, open market operations, controlling the reserve requirement ratio, and more.

Post Idea #29: Aducanumab

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Aducanumab: Evidence From Clinical Trial Data And Controversies

On 7 June 2021, the US FDA approved aducanumab, a human IgG1 anti-Aβ monoclonal antibody selective for Aβ aggregates, as the first disease-modifying treatment for AD. Aducanumab is approved in the United States for the treatment of mild cognitive impairment or mild-dementia stage of AD. In this Editorial, we review the trial data for aducanumab in the treatment of AD and the controversies that its approval has generated.

332.8The primary objective of the studies was to assess the efficacy of aducanumab in reducing cognitive decline measured on the CDR-SB.9 The secondary objectives were to evaluate the effect of aducanumab on the decline in MMSE, the Alzheimer’s Disease-Cognitive Subscale and on the Alzheimer’s Disease Cooperative Study-Activities of Daily Living-MCI. The tertiary efficacy objective for the two studies were to analyse the effect of aducanumab on neuropsychiatric symptoms as measured on the Neuropsychiatric Inventory-10, the safety and tolerability of aducanumab, and the pharmacokinetic and pharmacodynamic properties of aducanumab.

Differences in the incidence, severity, association with symptoms or management of ARIA with potential implications of functional unblinding were not considered factors for the differences in outcomes noted between Study 301 and Study 302.Statistical review and evaluation of aducanumab by the FDAThe statistical review and evaluation of aducanumab by the FDA stated that the available data did not seem to provide sufficient evidence to support the efficacy of high-dose aducanumab amongst individuals with AD.10 The reviewers noted several issues with the trial data regarding aducanumab.

The committee members voted, with 10 members against and 1 member uncertain that it was not reasonable to consider the evidence of clinical benefit from Study 302 as primary evidence of effectiveness of aducanumab for the treatment of AD and the vote being largely based on the conflicting results of Study 302 and Study 301.11,12.In their review, Alexander et al.

The Institute for Clinical and Economic Review report from May 2021 concluded that there was uncertainty about the benefits of aducanumab when used amongst individuals with AD and that there was evidence for harms with its use, with the current evidence being insufficient to determine the net health benefit of aducanumab.

Although many experts have reviewed the data from the aducanumab trials and published their commentaries based on this, the trial data have not been published in any peer-reviewed journal.

The controversies surrounding the FDA approval of aducanumab are worthy of further investigation so that the public regains trust in the review process not only for the potential promise of aducanumab but, even more importantly, for the future development of desperately needed disease-modifying therapies for this epidemic of our times.

Aducanumab Information

Aduhelm is an amyloid beta-directed antibody indicated to treat Alzheimer’s disease.

Aduhelm is approved under the accelerated approval pathway, which provides patients with a serious disease earlier access to drugs when there is an expectation of clinical benefit despite some uncertainty about the clinical benefit.

Accelerated approval is based upon the drug’s effect on a surrogate endpoint – an endpoint that reflects the effect of the drug on an important aspect of the disease – where the drug’s effect on the surrogate endpoint is expected, but not established, to predict clinical benefit.

In the case of Aduhelm, the surrogate endpoint is the reduction of amyloid beta plaque.

The accelerated approval pathway requires the company to verify clinical benefit in a post-approval trial.

If the sponsor cannot verify clinical benefit, FDA may initiate proceedings to withdraw approval of the drug.


Aducanumab was approved for medical use in the United States by the Food and Drug Administration in June 2021, in a controversial decision that led to the resignation of three advisers to the FDA in the absence of evidence that the drug is effective.

In November 2020, a panel of outside experts for the FDA concluded that a pivotal study of aducanumab failed to show “Strong evidence” that the drug worked, citing questionable efficacy and multiple “Red flags” found with the data analysis.

The Office of Inspector General, U.S. Department of Health and Human Services has been asked to investigate interaction between the drug company and the FDA prior to the drug’s approval.

Aducanumab was developed by Biogen Inc., which licensed the drug candidate from Neurimmune, who discovered it with the University of Zurich.

On 22 October 2019, Biogen announced that it would be restarting the FDA approval process for aducanumab stating that analysis of a larger dataset claimed that the drug reduced clinical decline in patients with early Alzheimer’s disease when given at higher doses.

In November 2020, a panel of outside experts on the FDA’s Peripheral and Central Nervous System Advisory Committee concluded that a pivotal study of aducanumab failed to show “Strong evidence” that the drug worked, along with potential safety issues, and suggested that the FDA not approve aducanumab, citing questionable efficacy and multiple “Red flags” found with the data analysis.

The June 2021 approval of the drug by the U.S. Food and Drug Administration is considered controversial because clinical trials gave conflicting results on its effectiveness.

AAN Calls For More Guidance For Aducanumab Use In Alzheimer Disease

The safe prescription of aducanumab, an amyloid-β-directed human immunoglobulin G1 monoclonal antibody, in patients with symptomatic Alzheimer disease will require a substantial investment in both human and physical infrastructure, according to a systematic review published in Neurology.

In the current study, a panel of researchers systematically reviewed the available clinical trial data that detailed the use of aducanumab in individuals with early symptomatic AD. The researchers assigned level of evidence statements, based on the 2017 American Academy of Neurology therapeutic classification of evidence scheme, and presented clinical considerations regarding use of the agent.

Overall, 1 of the trials was rated class I and 3 of them were rated class II. Trial 1 was a class I, phase 1, randomized, double-blind, placebo-controlled, single ascending-dose study of aducanumab in patients with mild to moderate AD dementia.

Trial 2 was a class II, phase 1, randomized, double-blind, placebo-controlled trial of multiple doses of aducanumab in patients with prodromal or mild AD. Trials 3 and 4 were identically designed class II, phase 3, randomized, double-blind, placebo-controlled studies that evaluated the safety and efficacy of aducanumab in patients with prodromal or mild symptomatic AD. Results of the class I study demonstrated that single doses of aducanumab of up to 30 mg/kg were safe and well tolerated.

Although efficacy data from the class II trials varied according to dose and outcome, aducanumab either had no effect on mean change in the Clinical Dementia Rating® Sum-of-Boxes scores or was associated with less worsening, which was of uncertain clinical significance.

The researchers concluded that “Evidence-based guidance is needed to address key questions and critical issues relating to access to aducanumab that will inform shared decision-making between patients and providers.”

Aducanumab use in symptomatic Alzheimer disease evidence in focus: report of the AAN Guidelines Subcommittee.

Biogen And Eisai Revise Agreements On Alzheimer’S Disease Therapies

Biogen and Eisai have revised their current partnership agreements on Alzheimer’s disease therapies, aducanumab and lecanemab.

Eisai will not take part in Aduhelm’s economics beyond these royalty payments once the tiered royalty model becomes effective next year.

The supply agreement linked to lecanemab for commercial production by Biogen has been increased to ten years from five years.

Biogen and Eisai will progress to carry out the co-development and co-commercialisation of lecanemab.

Eisai is in charge of the development and regulatory submissions linked to lecanemab globally while the companies are jointly commercialising and promoting it.

Both parties equally share the economics while Eisai handles complete sales of the product and Biogen is eligible for half of the profit and loss shares.

The lecanemab drug substance will be produced by Biogen in its facility in Solothurn, Switzerland, to offer a steady commercial supply of the therapy globally.

Aducanumab Approved For Treatment Of Alzheimer’S

Aducanumab has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration.

Aducanumab FAQs Is aducanumab a cure for Alzheimer’s and all other dementia?

Aducanumab is indicated for the treatment of Alzheimer’s disease.

Treatment with aducanumab may be appropriate for people in the disease stage studied in the clinical trials.

Understanding aducanumab Aducanumab could mean more time for individuals to actively participate in daily life, have sustained independence and hold on to memories longer.

The label says aducanumab is indicated for the treatment of Alzheimer’s, based on reduction in beta-amyloid plaques, one of the hallmarks of the disease.

Our 30-minute webinar about aducanumab features Dr. Salloway and Dr. Edelmayer reviewing what the treatment is, how it is administered, what it was designed to do, who is eligible to receive it and steps for accessing it.


One of Three Sites in Ohio Once treatment becomes available, UC Health will be one of only three hospitals in Ohio approved to administer the drug.

Forefront of Discovery UC Health will be participating in the ICARE international phase IV study, which will collect comprehensive information regarding patient experiences with Aducanumab.

Diagnostic Testing and Research Our cognitive disorders clinic is very experienced with and routinely uses biomarker diagnostic testing, longitudinal monitoring of cognition and function, and comprehensively investigates for all contributing factors related to brain health.

Innovative Care As an academic health system, we focus on providing world-class care, using innovative techniques and instruments that decrease complications and improve outcomes.

That’s why we set up a toolbox to share detailed information about your patient’s health with you.

CINCINNATI – UC Health, Greater Cincinnati’s academic health system, will be among just three sites in Ohio to offer Aducanumab, a new treatment for Alzheimer’s disease.

At UC Health, we lead the region in scientific discoveries and embrace a spirit of purpose – offering our patients and their families something beyond everyday healthcare.

Post Idea #30: Electro-optics

Related Articles – Summarized


Electro-optics is a branch of electrical engineering, electronic engineering, materials science, and material physics involving components, devices and systems which operate by the propagation and interaction of light with various tailored materials.

Thus it concerns the interaction between the electromagnetic and the electrical states of materials.

The electro-optic effect is a change in the optical properties of an optically active material due to interaction with light.

In a Kerr cell, the change in birefringence is proportional to the square of the optical electric field, and the material is usually a liquid.

In a Pockels cell, the change in birefringence varies linearly with the electric field, and the material is usually a crystal.

Non-crystalline, solid electro-optical materials have generated interest because of their low cost of production.

These organic, polymer-based materials are also known as organic EO material, plastic EO material, or polymer EO material.

ScienceDirect Topics

4Ti3O12 thin films have been reported to exhibit excellent optical properties, such as large optical nonlinearity and high optical transparency in the visible wavelength region, which are attractive for the potential uses in optic and optoelectronic device.

Optical switches utilizing electro-optic effect have tremendous potential for application of optical processing because of their small size, single-mode operation and polarization independence.

If a chirp parameter is defined by α=2PoutdΦct/dtdPoutt/dt, where Pout(t) is the output optical power and Φc(t) is the phase of the output optical field.

The length of the two electrode are not the same; they are L and xL, respectively, with 0 < x < 1.The chirp parameter is defined by α=2PoutdΦt/dtdPoutt/dt, where Pout(t) is the output optical power and Φ(t) is the phase of the output optical field.

If the modulator is biased at the quadrature point of the power transfer function with Vm = 0.2Vπ and = π/2, please find the optical powers of the 0th, 1, 2, and 3 harmonics of the optical spectrum.

The optical absorption and phase shift coefficients of the semiconductor material can be expressed in polynomial forms as Δα(V) = 0.015V3 0.05V and Δβ(V) = 0.2V2 V in [rad/mm], respectively, with reference to Eq.(a)Assume that the waveguide length is 2 mm, for a binary modulation with the two voltage levels of 0 and 5 V, what is the power extinction ratio of the modulated optical signal?

In addition to using an MZI as an optical filter, it is also often used as a wavelength interleaver, as shown in Figure 2.3.4(b) [11, 12]. In this application, a wavelength division multiplexed optical signal with narrow channel spacing can be interleaved into two groups of optical signals each with a doubled channel spacing compared to the input.

Electro-Optics Technology

Electro-Optics Technology has been supplying enabling components and diagnostic equipment worldwide for manufacturers and users of laser systems since 1987.

Electro-Optics Technology has invested extensively in our optical fabrication capabilities with the recent addition of two new facilities.

Through these vertical integration efforts, EOT is excited to present new, world-class capability and technology for our customers’ benefit.

Electro-Optics Technology utilizes an experienced group of engineers and technicians that work closely with customers from the beginning of the customer’s project and all the way through to production.

Current products include Faraday rotators and isolators for use with solid state and ultrafast lasers, VIS to Mid-IR semiconductor lasers, and fiber laser applications.

With our commitment to quality and innovation combined with our extensive and growing list of capabilities, Electro-Optics Technology is proud to be your total solutions provider.

EOT collaborates with customers to provide innovative, enabling laser components that represent the best value in terms of performance, reliability, and delivery.

Electro-Optics Center Of Excellence

Since its inception in 1999, the Electro-Optics Center has reduced acquisition, operational and life-cycle costs while simultaneously improving the mission capability of electro-optic military hardware and enabling the transition of technology to industry and ultimately to the warfighter.

Operated by the Penn State University Applied Research Laboratory in Freeport, PA, EOC is a hybrid between the best components of a university and those of private industry.

This relationship enables access to the university’s researchers and scientists, its state-of-the-art facilities and leading-edge research.

EOC and the partner members of its Electro-Optics Alliance have completed nearly 40 Navy ManTech projects that have resulted in significant savings to the taxpayer.

The EOA advances DoD critical electro-optic manufacturing science and technology, and promotes U.S. preeminence in all areas of electro-optics.

Alliance membership is available at no cost to all U.S. companies, government labs and academic institutions involved in electro-optics technology.

The EOA is committed to advancing the commercial viability of electro-optics technologies and promoting technology transfer to industry, as well as wide dissemination of new electro-optics-related information.

Kleertemp Thermometers

Electro-Optix has been manufacturing durable high quality magnifiers & optical magnifying products, in the United States for our Industrial, Military, Aeronautical, Medical, Retail, and Government customers for 50 years.

We have the World’s largest selection of Quality American Made magnifiers, loupes, Magnifying Glass, and optical inspection tools! Others only import and rebrand products, we manufactur in the USA. No one makes or offers more American made Magnifiers then Electro-Optix.

Electro-Optix has been producing magnifiers, loupes, and magnifying glass & vision aids for over 50 yrs in the United States.

Electro-Optix has private labeled and contract manufactured magnifiers and loupes for many of the best known optical and tool companies in the industry.

Unlike most of our competitors who simply import foreign made magnifiers and repackage them into their own brand, we make many of our products here in the USA. Electro-Optix continues to innovate , design and make products that are truly “Made in the USA”.

Our product line includes a full line of Magnifiers, Magnifying Glass, Handheld Magnifiers, illuminated magnifiers, dome magnifiers, optical inspection tools,measuring magnifiers, linen testers, loupes, Jewelers Loupes, & magnifying tweezers.

Magnifier.comOur Measuring Magnifier catalog at: www.

Post Idea #31: Electro-optical sensor

Related Articles – Summarized

What Is An Electro-Optical Sensor?

Such an optical sensor is typically part of a bigger system that brings together a source of light, a measuring device and the optical sensor; with the latter connected to an electrical trigger.

The trigger then responds to a change in the signal within the light sensor and the optical sensor tracks and measures the changes from one or many light beams.

A point sensor operates on a single point, whereas a distributed sensor functions over an array or a distribution of points.

If a light beam does not leave the optical fiber cable and is changed inside the cable itself, it is known as an intrinsic optical sensor.

When a light beam leaves the optical fiber cable or feed and is changed before it continues on its path till the optical detector, it is known as an extrinsic optical sensor.

The placement of the optical transmitter and receiver is also a major characteristic of the optical sensor.

A 2020 news article even reports about a breakthrough optical sensor that mimics the human eye; this is said to be a key step toward better AI. Strengths of electro-optical sensors.

Electro-Optical Sensor

An optical sensor converts light rays into electronic signals.

An optical sensor is generally part of a larger system that integrates a source of light, a measuring device and the optical sensor.

An optical sensor can measure the changes from one or several light beams.

An optical switch enables signals in optical fibres or integrated optical circuits to be switched selectively from one circuit to another.

Optical Switches are usually used in optical fibers, where the electro-optic effect is used to switch one circuit to another.

Among other applications, optical switches can be found in thermal methods which vary the refraction index in one leg of an interferometer in order to switch the signal, MEMS approaches involving arrays of micromirrors that can deflect an optical signal to the appropriate receiver, piezoelectric beam steering liquid crystals which rotate polarized light depending on the applied electric field and acousto-optic methods which change the refraction index as a result of strain induced by an acoustic field to deflect light.

Another important application of optical sensor is to measure the concentration of different compounds by both visible and infrared spectroscopy.

Electro-Optical And Infrared Sensors

Shipboard Panoramic EO/IR is a recently initiated US Surface Navy acquisition that will dramatically improve shipboard sensor system capabilities and will be fully integrated with combat management systems.

Northrop Grumman is poised to embark on our partnership with the Navy to fulfil our SPEIR vision to provide game-changing EO/IR technology, which can autonomously detect, track and identify air, and significantly improving navigation safety.

Northrop Grumman’s core competencies include extensive combat systems integration, as exemplified by the Fleet’s premier sea skimming anti-ship cruise missile detection system, the SPQ-9B radar, as well as broad experience in US Navy submarine CMS integration with radar systems.

Northrop Grumman has devoted several decades integrating the Fleet’s bedrock of navigation sensor systems including WSN-7 and NEXGEN WSN-12, Navy ECDIS, and Integrated Bridge systems.

Northrop Grumman also successfully fielded and currently maintains the Integrated Combat Management System onboard the Littoral Combat Ship Independence class variant.

Yokogawa Electric Corporation

Yokogawa is working on research and development of accurate sensing technology, particularly electric field sensing technology using applied optical measurements, to help our clients solve problems they encounter in the manufacturing setting.

We are focusing on applied optical measurement technology using electro-optic effects to achieve advanced electric field sensing.

EO sensors sense the electric field by measuring the polarization of laser beams transmitted by EO crystals whose birefringence changes in response to the applied electric field.

EO sensors have the following characteristics that make them applicable to the measurement of high-speed signals in electric circuits and radiation noise from electronic devices.

Low disturbance: Does not disturb the electric field from the target object, enabling measurement of the intact electric field distribution.

We aim to infer the characteristics of materials on manufacturing lines from the attenuation of transmitted/reflected electric field signals after irradiation of the materials.

At Yokogawa, we will continuously work to optimize the manufacturing process and create new value together with our customers by providing key devices that support the manufacturing industry, such as sensors and our control technology.

Main Families Of Electro-Optical Sensors

Situated between X rays and microwaves, the domain of optics deals with radiations of wavelengths approximately from 0.02 µm and 500 µm, and is divided into three parts : Ultraviolet, Visible, and Infrared.

If a sensor is supposed to operate in vacuum, there will not be any constraint emanating from the propagating medium concerning the best wavelength or spectral domain of operation.

If the radiation to be detected propagates through some medium before reaching the sensor, then that medium will impose some optimal spectal domain, or window especially if the propagation path is lengthy.

The most usual propagating medium is the atmosphere, which sets its limits between about 0.2 et 15 µm. Of course the optimal band is not the same for other media : blue-green for water, near IR for optical fibers.

Figure 3 : Spectral transmittance of the atmosphere.

Electro-optical sensors operating in the same spectral domain will share some similarities even if they functions are quite different.

This resemblance may concern for example the type of radiation they are dealing with, its origin, its propagation, or its detection.

Electrochemical Sensors For Hazardous Gas Detection

SemeaTech, a world leader in sensing technologies, offers a full line of electrochemical sensors for detecting hazardous materials and gases for work safety and environmental protection.

SemeaTech has built a wide network of industry experts and technologists to provide the company with guidance for customer needs and market requirements in order to release the right products featuring minimized environmental impact, no application errors, higher resolutions, increased sensitivity, improved stability, better exchangeability, wider measuring ranges, etc.

It is recommended that you mount the SemeaTech electrochemical sensors in a Socket where they can be removed and replaced when their working life expires.

What Is EO?/IR?

EO/IR systems are imaging systems used for military or law enforcement applications which include both visible and infrared sensors.

Critical features of EO/IR systems are long-range imaging abilities and image stabilization.

Common applications of EO/IR systems include airborne homeland security, combat, patrol, surveillance, reconnaissance, and search and rescue programs.

FLIR is committed to the development of EO/IR technology to enable professionals in their mission of saving lives and livelihoods.

FLIR Systems pioneered the first stabilized EO/IR systems, and since the 1990s has been a leader in long-range EO/IR sensors.

Current EO/IR sensors include the FLIR Star SAFIRE series of gimbals, with features such as internal navigation for precise targeting, MWIR thermal imaging, EO color and low-light cameras, and multiple laser payload options to ease identification and improve safety.

EO/IR technology is also being fit to smaller payloads, including traditional drones and the FLIR Black Hornet, a reconnaissance UAV that fits in the palm of a hand and transmits live video and still HD images back to the operator to improve their awareness and reduce risk to ground forces.

Post Idea #32: L3 Technologies

Related Articles – Summarized

L3 Technologies

L3 Technologies, formerly L-3 Communications Holdings, was an American company that supplied command and control, communications, intelligence, surveillance and reconnaissance systems and products, avionics, ocean products, training devices and services, instrumentation, aerospace, and navigation products.

TRL Technology, a specialist defense electronics company based in Gloucestershire, UK. TRL Technology is internationally known for development and innovation in the fields of interception, surveillance, electronic warfare, and communications.

As of January 1, 2018, Christopher E. Kubasik became chief executive officer and president of L3 Technologies.

On December 31, 2016, the company changed its name from L-3 Communications Holdings, Inc. to L3 Technologies, Inc. to better reflect the company’s wider focus since its founding in 1997.

The company’s website changed from L-3com.com to L3T.com, but the company’s NYSE ticker symbol of LLL remained the same.

A US Department of Defense investigation had reportedly found that the company had, “Used a highly sensitive government computer network to collect competitive business information for its own use.” A US federal criminal investigation ended the temporary suspension on July 27, 2010.

In 2015, L3 Technologies agreed to pay $25.6 million to settle a lawsuit with the U.S. Government.

L3Harris™ Fast. Forward.

Jacqui Nevils, Vice President and Chief Information Officer, L3Harris recently posted on International Women’s Day, sharing what it means to #BreaktheBias.

L3Harris Technologies’ third high-resolution weather instrument is set to launch March 1 onboard a NOAA satellite – strengthening the nation’s ability to monitor the environment and rapidly detect severe weather.

Working At L3Harris Technologies

Search All Jobs In United Kingdom L3Harris has provided products and services in Canada for more than five decades.

Search All Jobs In Canada L3Harris is involved with a full range of projects in India, supporting the nation’s civil and military goals.

From defense and paramilitary to public safety, aviation and space, L3Harris is providing the technologies for a modern, self-reliant India.

Search All Jobs In India Japan is strengthening its capabilities in space, cyberspace and the electromagnetic spectrum, which are core strengths of L3Harris.

Search All Jobs In Japan L3Harris has a strong presence in the Republic of Korea, providing defense technologies and solutions for over 25 years.

Search All Jobs In Republic of Korea Through its presence in Saudi Arabia, L3Harris supports the Kingdom’s goals to modernize, localize and develop an advanced military industry capability and continues to make significant program and engineering investments in the country.

Search All Jobs In Kingdom of Saudi Arabia For over 20 years in Singapore, L3Harris has demonstrated world-class engineering, manufacturing, research and development pedigree in working with the Singapore government and industry partners to solve complex problems and defend against evolving threats.

L3Harris™ Fast. Forward.

Jacqui Nevils, Vice President and Chief Information Officer, L3Harris recently posted on International Women’s Day, sharing what it means to #BreaktheBias.

L3Harris Technologies’ third high-resolution weather instrument is set to launch March 1 onboard a NOAA satellite – strengthening the nation’s ability to monitor the environment and rapidly detect severe weather.

Post Idea #33: Allosteric regulation

Related Articles – Summarized

Allosteric Regulation

The allosteric inhibitors of the aforementioned three enzymes are responsible for the observation by Pasteur that glycolysis is slower under aerobic conditions, when these allosteric inhibitors are present at higher concentrations.

Several high-O2 affinity Hb variants are caused by substitutions that inhibit interaction with allosteric activators such as 2,3-DPG, which normally binds between the β-globin chains to stimulate O2 release.

Catalytic Proteins – Enzymes Allosteric regulation of rate-limiting enzymes in metabolic pathwaysAllosteric enzymes display sigmoidal, rather than hyperbolic, plots of reaction rate versus substrate concentration.

In contrast, allosteric enzymes show sigmoidal plots of reaction velocity versus substrate concentration [S]. An allosteric effector molecule binds to the enzyme at a site that is distinct and physically separate from the substrate binding site and affects substrate binding and/orkcat.

They are.1Probe dependence: An allosteric effect observed with one receptor probe could be completely different for another probe; see Figure 7.20 and Figure 4.12.Figure 7.20.Figure 4.12.2Saturability of effect: That is, when the allosteric site is fully saturated, the effect stops; see Figure 4.10.3There can be separate effects on probe affinity and efficacy.

The reason for determining whether or not a given antagonism is allosteric in nature stems from the fact that allosteric and orthosteric antagonists have completely different properties and behaviors, and these can extend into their therapeutic use.

Inhibition curves for the allosteric modulator for CCR5 receptors, aplaviroc in blocking the binding of the chemokine RANTES and the CCR5-mediated calcium transient response to RANTES. It can be seen that aplaviroc produces a differentially greater inhibition of efficacy than affinity.

Allosteric Enzyme: Regulation Mechanism And Examples

Allosteric enzymes are enzymes that have an additional binding site for effector molecules other than the active site.

Allostery is the process of enzyme regulation, where binding at one site influences the binding at subsequent sites.

Allosteric Enzyme Properties Enzymes are the biological catalyst, which increases the rate of the reaction.

There can be more than one allosteric sites present in an enzyme molecule.

Allosteric Inhibition: When an inhibitor binds to the enzyme, all the active sites of the protein complex of the enzyme undergo conformational changes so that the activity of the enzyme decreases.

In other words, an allosteric inhibitor is a type of molecule which binds to the enzyme specifically at an allosteric site.

Which are allosteric enzymes?Which are allosteric enzymes?What are the three types of enzyme regulation?

Allosteric Regulation

In biochemistry, allosteric regulation is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme’s active site.

Ensemble models of allosteric regulation enumerate an allosteric system’s statistical ensemble as a function of its potential energy function, and then relate specific statistical measurements of allostery to specific energy terms in the energy function.

Allosteric modulation occurs when an effector binds to an allosteric site of an enzyme and alters the enzyme activity.

Allosteric modulators are designed to fit the allosteric site to cause a conformational change of the enzyme, in particular a change in the shape of the active site, which then causes a change in its activity.

Allosteric modulation of a receptor results from the binding of allosteric modulators at a different site from that of the endogenous ligand and enhances or inhibits the effects of the endogenous ligand.

These regulatory sites can each produce positive allosteric modulation, potentiating the activity of GABA. Diazepam is an positive allosteric modulator at the benzodiazepine regulatory site, and its antidote flumazenil is an antagonist.

Allosteric sites at the surface generally play regulatory roles that are fundamentally distinct from those within the interior; surface residues may serve as receptors or effector sites in allosteric signal transmission, whereas those within the interior may act to transmit such signals.

Definition Of Allosteric Regulation By Medical Dictionary

Pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function or to regulation of an enzyme involving cooperativity between multiple binding sites.

Allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme’s activity as a result of a change in its shape.

Al′lo·ster′i·cal·ly adv.

Allosteric Biochemistryadjective(1) Referring to allostery, see there.

2) Referring to the alteration of a binding site on a protein, usually an enzyme, due to interaction with another molecule.

Molecular biologyadjective Referring to the stereospecific modification of a protein by an effector to influence other protein- or nucleic acid-binding site activity.

Allosteric Regulation: Definition, Working And Significance

As is so often found in nature, the microscopic scale similarly works on a regulatory system of activation and inhibition of specific enzymes; this collection of processes is known as allosteric regulation.

Before we dig into the details of allosteric regulation, it is important to take a quick refresher on enzymes, namely their critical role in our body.

In the trillions of biochemical reactions happening in our cells every minute, enzymes play the key role of catalyzing those reactions.

Enzymes are reusable proteins that are tailored for a specific type of reaction within a series or cycle of reactions.

These sites on an enzyme include a binding site and a catalytic site, which temporarily hold the substrate in place and facilitate the chemical reaction, respectively.

Allosteric activation increases the attraction of active sites and substrates, while allosteric inhibition decreases the attraction between binding sites and potential substrates.

It is also important to note that such effector molecules can be either artificial or natural; our body uses the molecules available for allosteric control, when necessary, but humans have also figured out how to create functional allosteric regulation molecules.

Allosteric Regulation

ATP + AMP <--> 2 ADP. During intense exercise: large conversion of ATP to ADP with the muscle attempting to phosphorylate ADP back to ATP, this increase in ADP pushes the reaction to the left.

i.e. a 20% decrease in ATP leads to an almost 3-fold increase in ADP and ultimately a 1,400% increase in AMP. The increase in AMP is what’s important here……. Because AMP is an allosteric regulator that signals a low energy state in cells —–>.

Rise in AMP increases metabolism through pathways to restore energy.

Has a low Km so that it is active even at low glucose concentrations.

The concentration of AMP increases when energy is low.

> glycolysis must increase to meet energy demands by metabolizing glucose.

The two enzymes are reciprocally regulated or ATP would be lost without energy conservation.

Post Idea #34: Glucocerebrosidase

Related Articles – Summarized

ScienceDirect Topics

An unbiased analysis of all published GBA mutation carriers with PD through MDSGene is not yet available; thus, we will summarize important published data on NMS in GBA mutation carriers later.

Although not all participants were screened for mutations in the same comprehensive manner, the odds ratio for any GBA mutation in patients vs controls was 5.43.

PD patients with a GBA mutation presented earlier with the disease were more likely to have a positive family history and had a higher likelihood to present with atypical clinical manifestations than those without GBA mutations.

Several recent studies corroborated and extended the association of cognitive and psychiatric features in PD patients with GBA mutations: GBA mutations have been shown to be associated with a distinct cognitive profile characterized by greater impairment in working memory/executive function and visuospatial abilities.

PD patients with GBA mutations also have a significantly greater prevalence of depression vs iPD. Interestingly, post hoc analysis stratified by sex showed that male PD patients with GBA mutations had a higher burden of trait anxiety and depression than iPD patients, whereas GBA mutation-positive women did not have greater psychiatric morbidity compared to female iPD patients.

The glucocerebrosidase mutations were not found to be associated with the G2019S mutation in the leucine-rich repeat kinase 2 gene which encodes the protein dardarin, and has been associated with autosomal dominant, late onset Parkinson’s disease in both Askhenazi Jewish and non-Jewish subjects.

The key event in Parkinson’s disease linked to GBA mutations is thought to be a partial loss of glucocerebrosidase activity, which is similar to, but not as extreme as, that observed in Gaucher’s disease.


Measurement of glucocerebrosidase enzyme activity in leukocytes or skin fibroblasts on a skin biopsy is considered the ‘gold standard’ for diagnosing Gaucher disease.

5,6 If patients have leukopaenia, cultivated skin fibroblasts from a skin biopsy can be assayed instead.5 The determination of Gaucher disease must be made by specialised laboratories with particular experience in the measurement of glucocerebrosidase activity and its interpretation.

5-9 In patients with Gaucher disease, glucocerebrosidase activity levels are approximately 10‒30% of normal.

Residual glucocerebrosidase enzyme activity has been shown to significantly correlate with age, chitotriosidase enzyme activity, spleen size and greater disease severity in patients with Gaucher disease.

Measuring glucocerebrosidase enzyme activity does not distinguish between patients with Gaucher disease who are heterozygote carriers of mutations in the GBA1 gene and individuals who do not have Gaucher disease.

In healthy unaffected individuals without Gaucher disease, normal enzyme activity was reported as 1‒5 µmol/g prot/h for glucocerebrosidase and 4‒80 µmol/L/h for chitotriosidase.

A decrease in the activity of glucocerebrosidase was evident in 99% of patients diagnosed with Gaucher disease.

Glucocerebrosidase: Functions In And Beyond The Lysosome

Sidransky E., Sherer D.M., Ginns E.I. Gaucher disease in the neonate: A distinct Gaucher phenotype is analogous to a mouse model created by targeted disruption of the glucocerebrosidase gene.

Animal model of Gaucher’s disease from targeted disruption of the mouse glucocerebrosidase gene.

Van Weely S., Brandsma M., Strijland A., Tager J.M., Aerts J.M. Demonstration of the existence of a second, non-lysosomal glucocerebrosidase that is not deficient in Gaucher disease.

Tan Y.L., Genereux J.C., Pankow S., Aerts J.M., Yates J.R., III, Kelly J.W. ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher’s disease.

Multicenter analysis of glucocerebrosidase mutations in Parkinson’s disease.

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.


Domain III is homologous to a TIM barrel and is a highly conserved domain among glycoside hydrolases.

Domain III harbors the active site, which binds the substrate glucocerebroside in close proximity to the catalytic residues E340 and E235.

Conduritol B epoxide binds to the GCase active site, where the enzyme cleaves its epoxide ring, forming a permanent covalent bond between the enzyme and the inhibitor.

The lysosomal transporter and integral membrane protein LIMP-2 was shown to bind GCase and facilitate transport to the lysosome, demonstrating a mechanism for M6P-independent lysosomal trafficking.

Mutations in the glucocerebrosidase gene cause Gaucher’s disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides in macrophages that infiltrate many vital organs.

Mutations in the glucocerebrosidase gene are also associated with Parkinson’s disease.

Alglucerase was a version of glucocerebrosidase that was harvested from human placental tissue and then modified with enzymes.

Glucocerebrosidase: Functions In And Beyond The Lysosome

Glucocerebrosidase is a retaining β-glucosidase with acid pH optimum metabolizing the glycosphingolipid glucosylceramide to ceramide and glucose.

Inherited deficiency of GCase causes the lysosomal storage disorder named Gaucher disease.

In GCase-deficient GD patients the accumulation of GlcCer in lysosomes of tissue macrophages is prominent.

Based on the above, the key function of GCase as lysosomal hydrolase is well recognized, however it has become apparent that GCase fulfills in the human body at least one other key function beyond lysosomes.

Crucially, GCase generates ceramides from GlcCer molecules in the outer part of the skin, a process essential for optimal skin barrier property and survival.

This review covers the functions of GCase in and beyond lysosomes and also pays attention to the increasing insight in hitherto unexpected catalytic versatility of the enzyme.

Keywords: Gaucher disease; glucocerebrosidase; glucosylceramide; lysosome; skin.

What Is Glucocerebrosidase?

In the disorder known as Gaucher disease, a lack of glucocerebrosidase causes glucocerebroside to build up in the body, preventing organs such as the liver, spleen and bone marrow from working properly.

When the enzyme glucocerebrosidase is missing and glycolipid accumulates inside body organs, enlargement of the spleen and liver may develop together with lung disease and bone problems.

Other organs such as the skin may be affected, and glucocerebrosidase deficiency can give rise to three different forms of Gaucher disease, all with different collections of symptoms.

Mutations in the gene for glucocerebrosidase are thought to give rise to Gaucher disease.

Glucocerebrosidase mutations have also been identified in some patients with Parkinson’s disease, which suggests that the mutations may be a risk factor for the condition.

The outlook varies according to the severity of the condition, and treatment with glucocerebrosidase enzyme replacements allows some patients to attain a normal lifespan.

In type 2 Gaucher disease, glucocerebrosidase deficiency leads to glycolipid disrupting the nervous system and this typically leads to death in infancy.

GBA Gene: MedlinePlus Genetics

Changes in the GBA gene are also associated with Parkinson disease and parkinsonism, which are similar disorders that affect movement.

People with Gaucher disease have mutations in both copies of the GBA gene in each cell, while those with a mutation in just one copy of the gene are called carriers.

People with Gaucher disease and people who are carriers of a GBA gene mutation have an increased risk of developing Parkinson disease or parkinsonism.

More than 380 mutations in the GBA gene have been identified in people with Gaucher disease, a disorder with varied features that affect many parts of the body.

Most of the GBA gene mutations responsible for Gaucher disease change single protein building blocks in beta-glucocerebrosidase, altering the structure of the enzyme and preventing it from working normally.

Mutations in the GBA gene greatly reduce or eliminate the activity of beta-glucocerebrosidase in cells.

GBA gene mutations can increase the risk of developing dementia with Lewy bodies; however, some people with a mutation in the GBA gene never develop this condition.

Post Idea #35: Magna International

Related Articles – Summarized

Magna International

Magna International Inc. is a Canadian mobility technology company for automakers.

Stronach took Multimatic Investments public in 1969 through a merger with Magna Electronics Corporation, an aerospace, defense and industrial components company, and became known as Magna International in 1973.

In February 2015, Samsung SDI agreed to purchase the battery pack business from Magna Steyr, an Austrian operating unit of Magna International, for $120 million.

Magna International partnered with Argus Cyber Security after joining in a 2015 Series B funding round to access the company’s security technology.

Magna International is headquartered in Aurora, Ontario, and has 342 manufacturing operations and 91 product development, engineering and sales centres in 27 countries.

Magna acquired 80% of New Venture Gear, once a joint venture between General Motors and Chrysler, in September 2004, and combined it into Magna Powertrain.

During its history, Magna International has worked with automakers to advance vehicle safety and technology such as smart mobility seating systems including stow-into-floor minivan seats, exterior systems including reaction injection moulding bumpers, advanced driver assistance systems, blind-spot detection and lane departure warning systems.

Magna International, Inc. is a mobility technology company, which supplies to the automotive industry.

It operates through the following segments: Body Exteriors and Structures, Power and Vision, Seating Systems, and Complete Vehicles.

The Body Exteriors and Structures segment includes body and chassis systems, exterior systems and roof systems operations.

The Power and Vision segment comprises of global powertrain systems, electronics systems, mirrors and lighting and mechatronics operations.

The Complete Vehicles segment focuses on vehicle engineering and manufacturing operations.

The company was founded by Frank Stronach in 1957 and is headquartered in Aurora, Canada.

Looking at the universe of stocks we cover at Dividend Channel, on 11/23/16, Magna International Inc. will trade ex-dividend, for its quarterly dividend of $0.25, payable on 12/9/16.

Magna International Stock Forecast, Price & News

Magna International, Inc. is a mobility technology company, which supplies to the automotive industry.

It operates through the following segments: Body Exteriors and Structures, Power and Vision, Seating Systems, and Complete Vehicles.

The Body Exteriors and Structures segment includes body and chassis systems, exterior systems and roof systems operations.

The Power and Vision segment comprises of global powertrain systems, electronics systems, mirrors and lighting and mechatronics operations.

The Seating Systems segment deals with global seating systems operations.

The Complete Vehicles segment focuses on vehicle engineering and manufacturing operations.

The company was founded by Frank Stronach in 1957 and is headquartered in Aurora, Canada.

Electric Vehicle Spotlight: Magna International

As previously mentioned, Magna International has over 60 years of experience innovating all aspects of vehicles.

This includes New Entrant Fisker, for which Magna recently announced it will soon be producing an EV. The company considers itself “a 64-year-old startup,” so Magna International applies its experience with big innovations to a startup mentality.

Magna International’s Executive Vice President of R&D, Sherif Marakby, spoke with Electrek about the company’s current and future plans to accelerate vehicle electrification.

The modular approach allows Magna to work with its OEM customers to provide the most suitable configuration of electric drive(s) that best fit the vehicle.

Magna International developed the eBeam with the goal of electrifying one of the toughest vehicles, the pickup truck.

Since Magna International is a parts provider to nearly all major automakers, the eBeam can one day be implemented on different-sized chassis with different size batteries.

In developing driver assistance and AI technologies, Magna International truly is providing OEMs all components of a vehicle, inside and out.

Given current conditions, Magna is idling its Russian operations.

2025 Electric Heavy Duty Pickup first drive review: We drive Magna’s EtelligentForce prototype evpul.

Do you know anyone competing – if so, tell us about ’em! #Olympics2022 #OlympicsCan you imagine a without technology? We can’t! Today we recognize how technology changes the world and look to the future of technology.

As a Magna Sustainability Lead he believes we are all responsible for meeting our sustainability goals.

Magna teams in Wuhu, China, spent time scouring their plants to identify sustainable improvements Discover their findings below bit.

Ly/3mbhESyMeet Adriano Lima, Global Operational Excellence and Sustainability Manager, who believes that getting everyone engaged and sharing best practices will help us achieve our sustainability vision.

Ly/3ENMtUETune in December 7th to hear from Tom Rucker, Magna Powertrain President, as he discusses electrification and the future of electric vehicles.

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